Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-27T05:02:17.662Z Has data issue: false hasContentIssue false
  • English
  • Français

Erythema multiforme after application of aural Gentisone HC drops

Published online by Cambridge University Press:  29 June 2007

M. A. Siddiq
M. A. Siddiq*
Affiliation:
Department of Otolaryngology, The Leicester Royal Infirmary, Leicester, UK.
*
Address for correspondence: Mr M. A. Siddiq, F.R.C.S.(Ed.), 125 Broadway, Walsall, West Midlands WS1 3HB.
Get access Rights & Permissions [Opens in a new window]

Abstract

Erythema multiforme is an uncommon acute self-limiting condition characterized by mucocutaneous lesions of varying severity with a variable pattern of recurrence. This is a case of a four-year-old girl who developed erythema multiforme secondary to topical aural application of Gentisone HC drops (hydrocortisone acetate one per cent, gentamicin 0.3 per cent (as sulphate)) prescribed as a treatment for otorrhoea following grommet insertion. The clinical features are described and the literature reviewed. To my knowledge, this is the first reported case in the literature, of erythema multiforme secondary to a topical aminoglycoside/steroid preparation.

Keywords

Erythema multiformeAminoglycosidesStevens-Johnson syndromeGentamicin
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 113 , Issue 11 , November 1999 , pp. 1002 - 1003
Copyright
Copyright © JLO (1984) Limited 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Al-Ubaidy, S. S., Nally, F. F. (1976) Erythema multiforme: Review of 26 cases. Oral Surgery, Oral Medicine and Oral Pathology 41: 601–606.Google Scholar
Beveridge, J., Harris, M., Wise, G., Stevens, L. (1964) Long acting sulphonamides associated with Stevens-Johnson syndrome. Lancet 2: 593.CrossRefGoogle ScholarPubMed
Curley, R. K., Verbov, J. L. (1986) Stevens-Johnson syndrome due to tetracyclines – a case report (doxycycline) and review of the literature. Clinical and Experimental Dermatology 12: 124–125.CrossRefGoogle Scholar
Gottschalk, H. R., Stone, O. J. (1976) Stevens-Johnson syndrome from ophthalmic sulfonamide. Archives of Dermatology 112: 513–514.Google Scholar
Hebra, F. von (1866) On diseases of the skin including the exanthemata, Translated by Fagge, C.H., London (1866) New Sydenham Society. Vol. 1, pp 285–289.Google Scholar
Huff, J. C., Weston, W. L., Tonnesan, M. G. (1983) Erythema multiforme: A critical review of characteristics, diagnostic criteria and causes. Journal of the American Academy of Dermatology 8: 763–775.Google Scholar
Hurwitz, S. (1990)Erythema multiforme: A review of its characteristics, diagnostic criteria and management. Pediatrics in Review 11: 217–222.CrossRefGoogle ScholarPubMed
Kennett, S. (1968) Erythema multiforme affecting the oral cavity. Oral Surgery, Oral Medicine and Oral Pathology 25: 366–373.Google Scholar
Lozada, F., Silverman, S. (1978) Erythema multiforme: Clinical characteristics and natural history in fifty patients. Oral Surgery, Oral Medicine and Oral Pathology 46: 628–636.Google Scholar
Meneghini, C. L., Angelini, G. (1982) Contact dermatitis from pyrrolnitrin. Contact Dermatitis 8: 55–58.CrossRefGoogle ScholarPubMed
Murray, K. M., Camp, M. S. (1992) Cephalexin-induced Stevens-Johnson syndrome. Annals of Pharmacotherapy 26: 1230–1233.Google Scholar
Sarkar, S. K., Purohit, S. D., Sharma, T. N., Chawia, M. P., Gupta, D. N. (1982) Stevens-Johnson syndrome caused by streptomycin. Tubercle 63: 137–138.CrossRefGoogle ScholarPubMed
Schofield, J. K., Tatnall, F. M., Leigh, I. M. (1993) Recurrent erythema multiforme: clinical features and treatment in a large series of patients. British Journal of Dermatology 128: 542–545.Google Scholar
Stevens, A. M., Johnson, F. C. (1922) A new eruptive fever associated with stomatitis and ophthalmia. American Journal of Diseases Children 24: 526–533.Google Scholar
Stingeni, L., Caraffini, S., Assalve, D., Lapomarda, V., Lisi, P. (1996) Erythema-multiforme-like contact dermatitis from budesonide. Contact Dermatitis 34: 154–155.Google Scholar
Thomas, B. A. (1950) The so-called Stevens Johnson syndrome. British Medical Journal 1: 1393–1397.Google Scholar
Ting, H. C., Adam, B. A. (1984) Erythema multiforme: Response to corticosteroids. Dermatologica 169: 175–184.CrossRefGoogle Scholar
Valsecchi, R., Tornaghi, A., Tribbia, G., Cainelli, T. (1982) Contact dermatitis from Econazole. Contact Dermatitis 8: 422.CrossRefGoogle ScholarPubMed
Viraben, R., Labrousse, J. L., Bazex, J. (1990) Erythema multiforme due to DNCB. Contact Dermatitis 22: 179.CrossRefGoogle ScholarPubMed