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Extraskeletal Ewing’s sarcoma of the nose

Published online by Cambridge University Press:  08 March 2006

Andrej Böör ,
Ivan Jurkovič ,
Imrich Friedmann ,
Lukás Plank  and
Pavol Kočan
Andrej Böör
Affiliation:
Institute of Pathology, Medical Faculty, P. J. šafárik’s University, Košice, Slovak Republic.
Ivan Jurkovič
Affiliation:
Institute of Pathology, Medical Faculty, P. J. šafárik’s University, Košice, Slovak Republic.
Imrich Friedmann
Affiliation:
Department of Cell Pathology, Northwick Park and St. Mark’s Hospitals, Harrow, Middlesex, UK.
Lukás Plank
Affiliation:
Institute of Pathology, Jessenius Medical Faculty, Commenius University, Martin, Slovak Republic.
Pavol Kočan
Affiliation:
Institute of Pathology, Medical Faculty, P. J. šafárik’s University, Košice, Slovak Republic.
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Abstract

A 20-year-old woman presented with nasal obstruction and slight epistaxis. The obstructing lesion was excised and microscopy showed a neoplasm composed of comparatively uniform undifferentiated cells forming solid nests. The cytoplasm of the cells was clear but poorly demarcated, partly vacuolated and contained much glycogen. Although widespread in the nasal mucosa, the cells did not penetrate into the underlying bone.

The cells expressed the MIC2 gene (using the CD99 marker). Electron microscopy showed simple cells with a small number of mitochondria, many glycogen particles; there were no neurosecretory granules present.

Early surgical treatment followed by chemo- and radiotherapy have greatly improved the prognosis of EWS: extraskeletal Ewing’s sarcoma (EWS/PNET).

Keywords

Nose NeoplasmsSarcomaEwing’s
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 115 , Issue 1 , January 2001 , pp. 74 - 76
Copyright
© Royal Society of Medicine Press Limited 2001

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