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Head and neck squamous cell cancer associated with lymphoproliferative malignancies is aggressive

Published online by Cambridge University Press:  20 April 2020

L Li ,
L Hamilton ,
J Montgomery  and
M Stewart
L Li*
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
L Hamilton
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
J Montgomery
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
M Stewart
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
*
Author for correspondence: Dr Lucy Li, Department of Otolaryngology, Queen Elizabeth University Hospital, GlasgowG51 4TF, Scotland, UK E-mail: Lucy.li2@nhs.net
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Abstract

Background

Patients with non-Hodgkin's lymphoma and chronic lymphocytic leukaemia are at an elevated risk of further malignancy. Head and neck squamous cell carcinoma often presents with cervical lymph node metastasis, and can pose a diagnostic challenge in patients with non-Hodgkin's lymphoma or chronic lymphocytic leukaemia who may have pre-existing palpable neck nodes.

Methods

A retrospective case review of a health board was conducted to identify patients with head and neck squamous cell carcinoma with a previous diagnosis of non-Hodgkin's lymphoma or chronic lymphocytic leukaemia.

Results

Four patients with head and neck squamous cell carcinoma that developed after non-Hodgkin's lymphoma or chronic lymphocytic leukaemia were identified. Two patients had a background of non-Hodgkin's lymphoma treated with chemotherapy. The remaining two patients had a background of chronic lymphocytic leukaemia under active surveillance. Three out of the four patients died within 30 months of diagnosis.

Conclusion

Head and neck squamous cell carcinoma following non-Hodgkin's lymphoma or chronic lymphocytic leukaemia is aggressive. A heightened clinical suspicion is essential to facilitate early diagnosis and treatment of head and neck squamous cell carcinoma in patients with dual pathology.

Keywords

Metachronous NeoplasmsSquamous Cell Carcinoma Of Head And NeckHuman Papilloma VirusChronic Lymphocytic LeukemiaNon-Hodgkin's Lymphoma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 134 , Issue 5 , May 2020 , pp. 460 - 462
Copyright
Copyright © JLO (1984) Limited, 2020

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Footnotes

Dr L Li takes responsibility for the integrity of the content of the paper

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