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Intratympanic gentamicin treatment for unilateral Ménière's disease: long-term follow up of a proven regime

Published online by Cambridge University Press:  07 December 2012

J Wasson ,
N Upile  and
A Pfleiderer
J Wasson*
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital, UK
N Upile
Affiliation:
Department of Otolaryngology, Peterborough City Hospital, UK
A Pfleiderer
Affiliation:
Department of Otolaryngology, Peterborough City Hospital, UK
*
Address for correspondence: Mr J Wasson, 80 Tenison Rd, Cambridge CB1 2DW, UK E-mail: josephwasson@hotmail.com
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Abstract

Objective:

To determine the long-term efficacy of a fixed-dose intratympanic gentamicin treatment regime in controlling unilateral Ménière's disease.

Methods:

Pfleiderer (1998) published two-year follow-up results for a series of 16 patients treated with a 4-day, 12-dose intratympanic gentamicin regime for unilateral Ménière's disease that was refractory to medical treatment. In 2010, a long-term telephone follow up (mean 17 years and 3 months) of this same cohort was conducted to determine long-term vertigo control. Of the 16 patients, 13 were eligible for the long-term follow up.

Results:

At 2 years' follow up, all 16 patients experienced substantial control of vertigo, with complete control achieved in 87 per cent of cases. At the long-term follow up, 9 of the 13 eligible patients were contactable, and all reported complete control of vertigo.

Conclusion:

Fixed-dose intratympanic gentamicin controlled symptomatic unilateral Ménière's disease in both the short and long term.

Keywords

Ménière's diseaseVertigoPostural BalanceGentamicinTherapeuticsFollow-up Studies
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 20 - 24
Copyright
Copyright © JLO (1984) Limited 2012

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