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Investigation of smell and taste function in patients with obstructive sleep apnoea syndrome

Published online by Cambridge University Press:  22 April 2019

A Yenigun ,
N Degirmenci ,
S S Goktas ,
R Dogan  and
O Ozturan
A Yenigun*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
N Degirmenci
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
S S Goktas
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
R Dogan
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
O Ozturan
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
*
Author for correspondence: Dr Alper Yenigun, Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Vatan Street, 34093 Fatih, Istanbul, Turkey E-mail: alperyenigun@gmail.com Fax: +90 (212) 453 18 70
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Abstract

Objective

This study investigated the relationship between disease severity and taste and smell functions in patients with obstructive sleep apnoea syndrome.

Methods

A total of 65 patients with recurrent upper airway obstruction during sleep were included. Participants were divided into four groups according to apnoea-hypopnoea index, obtained on polysomnography. Smell and taste tests were performed on these patients.

Results

A significant difference was observed between the smell thresholds of the groups for the identification test (p = 0.016). In the taste test, significant differences were observed between the groups in terms of sweet, sour, salty and bitter taste test thresholds (p = 0.029, p = 0.0005, p = 0.001 and p = 0.017, respectively).

Conclusion

As sleep apnoea severity increased (according to the apnoea-hypopnoea index) in obstructive sleep apnoea syndrome patients, the taste and smell thresholds decreased due to the effect of neuropathy and inflammation in the upper respiratory tract.

Keywords

Obstructive Sleep Apnea SyndromeSense of SmellTaste SenseInflammation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 5 , May 2019 , pp. 376 - 379
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr A Yenigun takes responsibility for the integrity of the content of the paper

References

1Silva, GE, An, M-W, Goodwin, JL, Shahar, E, Redline, S, Resnick, H et al. Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS). Sleep 2009;32:1049–57Google Scholar
2Berger, G, Berger, R, Oksenberg, A. Progression of snoring and obstructive sleep apnoea: the role of increasing weight and time. Eur Respir J 2009;33:338–45Google Scholar
3Andrews, JG, Oei, TPS. The roles of depression and anxiety in the understanding and treatment of obstructive sleep apnea syndrome. Clin Psychol Rev 2004;24:1031–49Google Scholar
4Kushida, CA, Littner, MR, Morgenthaler, T, Alessi, CA, Bailey, D, Coleman, J et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 2005;28:499–521Google Scholar
5Yarmolinsky, DA, Zuker, CS, Ryba, NJP. Common sense about taste: from mammals to insects. Cell 2009;139:234–44Google Scholar
6Fark, T, Hummel, C, Hähner, A, Nin, T, Hummel, T. Characteristics of taste disorders. Eur Arch Otorhinolaryngol 2013;270:1855–60Google Scholar
7Landis, BN, Welge-Luessen, A, Brämerson, A, Bende, M, Mueller, CA, Nordin, S et al. “Taste Strips” - a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol 2009;256:242–8Google Scholar
8Takeuchi, T, Futatsuka, M, Imanishi, H, Yamada, S. Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health 1986;12:280–3Google Scholar
9Strömberg, T, Dahlin, LB, Lundborg, G. Hand problems in 100 vibration-exposed symptomatic male workers. J Hand Surg Br 1996;21:315–19Google Scholar
10Virokannas, H. Dose-response relation between exposure to two types of hand-arm vibration and sensorineural perception of vibration. Occup Environ Med 1995;52:332–6Google Scholar
11Svanborg, E. Impact of obstructive apnea syndrome on upper airway respiratory muscles. Respir Physiol Neurobiol 2005;147:263–72Google Scholar
12Yenigun, A, Karamanli, H. Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome. J Laryngol Otol 2015;129:887–92Google Scholar
13Hori, T, Sugita, Y, Koga, E, Shirakawa, S, Inoue, K, Uchida, S et al. Proposed supplements and amendments to ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’, the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci 2001;55:305–10Google Scholar
14Gould, GA, Whyte, KF, Rhind, GB, Airlie, MA, Catterall, JR, Shapiro, CM et al. The sleep hypopnea syndrome. Am Rev Respir Dis 1988;137:895–8Google Scholar
15Cain, WS, Gent, JF, Goodspeed, RB, Leonard, G. Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 1988;98:83–8Google Scholar
16Garvey, JF, Taylor, CT, McNicholas, WT. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation. Eur Respir J 2009;33:1195–205Google Scholar
17Friberg, D, Ansved, T, Borg, K, Carlsson-Nordlander, B, Larsson, H, Svanborg, E. Histological indications of a progressive snorers disease in an upper airway muscle. Am J Respir Crit Care Med 1998;157:586–93Google Scholar
18Hagander, L, Harlid, R, Svanborg, E. Quantitative sensory testing in the oropharynx: a means of showing nervous lesions in patients with obstructive sleep apnea and snoring. Chest 2009;136:481–9Google Scholar
19Kimoff, RJ, Sforza, E, Champagne, V, Ofiara, L, Gendron, D. Upper airway sensation in snoring and obstructive sleep apnea. Am J Respir Crit Care Med 2001;164:250–5Google Scholar
20Guilleminault, C, Li, K, Chen, N-H, Poyares, D. Two-point palatal discrimination in patients with upper airway resistance syndrome, obstructive sleep apnea syndrome, and normal control subjects. Chest 2002;122:866–70Google Scholar
21Nguyen, ATD, Jobin, V, Payne, R, Beauregard, J, Naor, N, Kimoff, RJ. Laryngeal and velopharyngeal sensory impairment in obstructive sleep apnea. Sleep 2005;28:585–93Google Scholar
22Mackenzie, RA, Skuse, NF, Lethlean, AK. A micro-electrode study of peripheral neuropathy in man. Part 1. Responses to single graded stimuli. J Neurol Sci 1977;34:157–74Google Scholar
23Friberg, D, Gazelius, B, Hökfelt, T, Nordlander, B. Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers. Regul Pept 1997;71:29–36Google Scholar
24Friberg, D, Gazelius, B, Lindblad, LE, Nordlander, B. Habitual snorers and sleep apnoics have abnormal vascular reactions of the soft palatal mucosa on afferent nerve stimulation. Laryngoscope 1998;108:431–6Google Scholar
25Sunnergren, O, Broström, A, Svanborg, E. Soft palate sensory neuropathy in the pathogenesis of obstructive sleep apnea. Laryngoscope 2011;121:451–6Google Scholar
26Jeong, KH, Yang, Y, Choi, HR, Cho, JH, Kim, GT, Kim, JK. Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination. Clin Exp Otorhinolaryngol 2016;9:226–32Google Scholar