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KIT and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma

Published online by Cambridge University Press:  11 June 2010

T Kanazawa ,
M Nokubi ,
K Takizawa ,
S Matsuzawa ,
A Shinnabe ,
H Mineta  and
Y Iino
T Kanazawa*
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
M Nokubi
Affiliation:
Department of Pathology, Jichi Medical University Saitama Medical Center, Japan
K Takizawa
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
S Matsuzawa
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
A Shinnabe
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
H Mineta
Affiliation:
Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Japan
Y Iino
Affiliation:
Department of Otolaryngology, Jichi Medical University Saitama Medical Center, Japan
*
Address for correspondence: Dr Takeharu Kanazawa, Department of Otolaryngology, Head and Neck Surgery, Jichi Medical University Saitama Medical Center, 857-1 Amanuma, Omiya, Saitama City, Saitama, 330-8503Japan. Fax: + 81 48 648 5188 E-mail: kanatake@omiya.jichi.ac.jp
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Abstract

Objective:

Small cell carcinoma has the worst prognosis of all laryngeal neoplasms. In order to further characterise this tumour, with a view to development of new therapeutic approaches, we report the results of KIT gene and platelet-derived growth factor receptor α gene expression analysis, for two extremely rare cases of primary small cell carcinoma of the larynx.

Method:

Case reports, including immunohistochemical study, and review of the literature.

Results:

We present two patients with laryngeal small cell carcinoma, who died from tumour metastasis to the lungs and brain despite aggressive treatment. Immunohistochemical studies revealed positive reactions for KIT gene expression and platelet-derived growth factor α gene expression in patient one, and for KIT gene expression in patient two. Molecular genetic analysis, using polymerase chain reaction direct sequencing, identified no mutations of the KIT or platelet-derived growth factor receptor α genes.

Conclusion:

Although further investigation is necessary regarding KIT gene expression and platelet-derived growth factor receptor α gene expression in laryngeal small cell carcinoma, the reported results suggest that these genes may be significant in the development of molecular targeted therapy.

Keywords

Neuroendocrine TumorsHead And Neck NeoplasmsBiological TherapySmall Cell CarcinomaLarynxPlatelet-Derived Growth Factor Receptor AlphaKIT
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 12 , December 2010 , pp. 1340 - 1343
Copyright
Copyright © JLO (1984) Limited 2010

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