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Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study

Published online by Cambridge University Press:  29 June 2007

Takuya Sugimoto ,
Shigeki Wakizono ,
Takuya Uemura ,
Masazumi Tsuneyoshi  and
Munetomo Enjoji
Takuya Sugimoto*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Shigeki Wakizono
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Takuya Uemura
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Masazumi Tsuneyoshi
Affiliation:
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Munetomo Enjoji
Affiliation:
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
*
Takuya Sugimoto, M.D., Department of Otorhinolaryngology, School of Medicine,University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807, Japan. Fax: 010-81-93-601-7554
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Abstract

A rare case of a 71 -year-old man with malignant oncocytoma is presented. The tumour was found in the left parotid region with enlarged lymph nodes in the neck. The resected parotid mass consisted of three discrete nodules, each histologically characterized by a uniform proliferation of oncocytic tumour cells. The patient underwent repeated operations for recurrences and metastases, and eventually died of acute pneumonia 18 months after the first admission. Metastases to the lymph nodes, ribs, spine and liver had been clinically pointed out. Immunohistochemically, the tumour cells were positive for a-1-antitrypsin, a-1-antichymotrypsin, lactoferrin, secretory component and carcinoembryonic antigen (CEA), while they were negative for S-100 protein and HHF35 (muscle specific actin). Ultrastructural pictures disclosed numerous mitochondria in the cytoplasm of the tumour cells, revealing neither myofibrils nor secretory granules. These findings therefore support the concept that this tumour is of a glandular epithelial origin.

Keywords

Parotid neoplasmsmalignant oncocytoma
Type
Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 1 , January 1993 , pp. 69 - 74
Copyright
Copyright © JLO (1984) Limited 1993

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