Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-11T07:38:46.715Z Has data issue: false hasContentIssue false
  • English
  • Français

Medullary (thyroid) carcinoma-like carcinoids of the larynx

Published online by Cambridge University Press:  29 June 2007

Adel K. El-Naggar ,
John G. Batsakis ,
Rena Vassilopoulou-Sellin ,
Nelson G. Ordonez  and
Mario A Luna
Adel K. El-Naggar
Affiliation:
Departments of Pathology. The university of Texas, M.D. Anderson Cancer Center, Houston, Texas.
John G. Batsakis*
Affiliation:
Departments of Pathology. The university of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Rena Vassilopoulou-Sellin
Affiliation:
Departments of Endocrinology. The university of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Nelson G. Ordonez
Affiliation:
Departments of Pathology. The university of Texas, M.D. Anderson Cancer Center, Houston, Texas.
Mario A Luna
Affiliation:
Departments of Pathology. The university of Texas, M.D. Anderson Cancer Center, Houston, Texas.
*
John G. Batsakis, M.D., Department of Pathology, Box 85, 1515 Holcombe Blvd., Houston, Texas 77030.
Get access Rights & Permissions [Opens in a new window]

Abstract

The histopathological spectrum of neuroendocrine neoplasms of the larynx includes a subset that may be indistinguishable from a medullary carcinoma of the thyroid gland. For a patient who presents with a medullary carcinoma-like metastasis in a cervicallymph node and in whom there is no clinically demonstrable thyroid lesion, a laryngeal atypical carcinoid must be excluded. The literature's third example ofa primary medullary carcinoma-like atypical carcinoid of the larynx is presented.

Keywords

Laryngeal neoplasmsCarcinoid
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 8 , August 1991 , pp. 683 - 686
Copyright
Copyright © JLO (1984) Limited 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Batsakis, J. G. (1987) Laryngeal involvement by thyroid disease. Annals of Otology, Rhinology and Laryngology, 96: 718–719.CrossRefGoogle ScholarPubMed
Clarke, R., Dickson, R. B., Briinner, N. (1990) The process of malignant progression in human breast cancer. Annals of Oncology, 1: 401–407.CrossRefGoogle ScholarPubMed
Djalilian, M., Beahrs, O. H., Devine, K. D., Weiland, L. H., DeSanto, L. W. (1974) Intraluminal involvement of the larynx and trachea by thyroid cancer. American Journal of Surgical Pathology, 128: 500–504.Google ScholarPubMed
Ferlito, A., Friedmann, I. (1989) Review of neuroendocrine carcinomas of the larynx. Annals of Otology, Rhinology and Laryngology, 98: 780–790.CrossRefGoogle ScholarPubMed
Friedman, M., Shelton, V. K., Skolnik, E. M., Berlinger, F. G., Arab, M. (1982) Laryngeotracheal invasion by thyroid carcinoma. Annals of Otology, Rhinology and Laryngology, 91: 363–369.CrossRefGoogle Scholar
Hedley, D. W., Friedlander, M. L., Taylor, I. W., Rugg, C. A., Musgrove, E. A. (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. Journal of Histochemistry and Cytochemistry, 31: 1333–1335.CrossRefGoogle ScholarPubMed
Hsu, S. M., Raine, L., Fanger, H. (1981) Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures. Journal of Histochemistry and Cytochemistry, 29: 577–580.CrossRefGoogle Scholar
James, C. D., Carlbom, E., Dumanski, J. P., Hansen, M., Nordenskjold, M., Collins, V. P., Cavenee, W. K. (1988) Clonal genomic alterations in glioma malignancy stages. CancerResearch, 48: 5546–5551.Google ScholarPubMed
Rotenberg, D., Lawson, V. G., Van Nostrand, A. W. P. (1979). Thyroid carcinoma presenting as a tracheal tumour. Case report and literature review with reflections on pathogenesis. Journal of Otolaryngology, 8: 401–410.Google ScholarPubMed
Smets, G., Warson, F., Dehou, M. F., Storme, G., Sacre, R., VanBelle, S., Somers, G., Gepts, W., Kloppel, G. (1990) Metastasizing neuroendocrine carcinoma of the larynxwith calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma. Virchows Archiv (A) Pathological Anatomy and Histopathology, 416: 539–543.CrossRefGoogle Scholar
Sweeney, E. C., McDonnell, L., O'Brien, C. (1981) Medullary carcinoma of the thyroid presenting as tumours of the pharynx and larynx. Histopathology, 5: 263–275.CrossRefGoogle ScholarPubMed
Wenig, B. M., Hyams, V. J., Heffner, D. K. (1988) Moderately differentiated neuroendocrine carcinoma of the larynx. A clinicopathologic study of 54 cases. Cancer, 62: 2658–2676.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Woodruff, J. M., Shah, J. P., Huvos, A. G., Gerold, F. P., Erlandson, R. A. (1985) Neuroendocrine carcinoma of the larynx. Astudy of two types, one of which mimics thyroid medullary carcinoma. American Journal of Surgical Pathology, 9: 771–790.CrossRefGoogle Scholar