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Metastasizing malignant oncocytoma of the submandibular gland

Published online by Cambridge University Press:  29 June 2007

C. G. Mahnke
Affiliation:
Departments of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.
U. Jänig
Affiliation:
Departments of Paedopathology, University of Kiel, Germany.
J. A. Werner*
Affiliation:
Departments of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany.
*
Address for correspondence: Priv.Doz. Dr J. A. Werner, Department of Otolaryngology, Head and Neck Surgery, University of Kiel, Arnold-Heller-Str. 14, D-24105 Kiel, Germany. Fax: +49-431-597 2272 e-mail: j.a.werner@t-online.de

Abstract

Malignant oncocytomas are extremely rare tumours of the salivary glands. Fewer than 50 cases have been reported in the world literature so far, 34 of which were located in the parotid gland. Only three of these tumours have been located in the submandibular gland. We report one further case of a malignant oncocytoma of the submandibular gland in a 47-year-old man. Since a definite histological diagnosis of malignant oncocytoma can rarely be made both clinical and histopathological findings are essential in establishing the diagnosis. Treatment consists of wide surgical excision, neck dissection and post-operative radiotherapy. The prognosis with regard to five-year survival is poor becauseof metastatic disease.

Type
Pathology in Focus
Copyright
Copyright © JLO (1984) Limited 1998

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References

Bauer, W. H., Bauer, J. D. (1953) Classification of glandular tumors of the salivary glands–Study of 143 cases. Archives of Pathology 55: 328346.Google Scholar
Batsakis, J. G. (1974) Tumors of the head and neck. Clinical and pathological considerations. Baltimore: Williams and Wilkins Company, pp 2729.Google Scholar
Brandwein, M. S., Huvos, A. G. (1991) Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. American Journal of Surgical Pathology 15: 514528.CrossRefGoogle ScholarPubMed
Chang, A., Harawi, S. J. (1992) Oncocytes, oncocytosis, and oncocytotic tumors. Pathology Annual 1: 263304.Google Scholar
Chu, W., Strawitz, J. G. (1978) Oncocytoma of the parotid gland with malignant change. Archives of Surgery 113: 318319.CrossRefGoogle ScholarPubMed
Ellis, G. L., Auclair, P. L., Gnepp, D. R., Goode, R. K. (1991) Other malignant epithelial neoplasms. In Surgical Pathology of the Salivary Glands. (Ellis, G. L., Auclair, P. L., Gnepp, D. R., eds.) W. B. Saunders, Philadelphia, London, Toronto, Montreal, Sydney, Tokyo, pp 455488.Google Scholar
Goode, R. K., Corio, R. L. (1988) Oncocytic adenocarcinomaof salivary glands. Oral Surgery Oral Medicine Oral Pathology 65: 6166.CrossRefGoogle Scholar
Hamed, G., Shmookler, B. M., Ellis, G. L., Punja, U.,Feldman, D. (1994) Oncocytic mucoepidermoid carcinoma of the parotid gland. Archives of Pathology and Laboratory Medicine 118: 313314.Google ScholarPubMed
Hamperl, H. (1931) Beiträge zur normalen und pathologischen Histologie menschlicher Speicheldrüsen. Zeitschrift für mikroskopisch-anatomische Forschung 27: 155.Google Scholar
Harker, L. A. (1977) Limitations of pathologic diagnosis in salivary tumors. Laryngoscope 87: 18991903.CrossRefGoogle Scholar
Johns, M. E., Batsakis, J. G., Short, C. D. (1973) Oncocytic and oncocytoid tumors of the salivary glands. Laryngoscope 83: 19401952.CrossRefGoogle ScholarPubMed
Johns, M. E., Regezi, J. A., Batsakis, J. G. (1977) Oncocytic neoplasms of salivary glands: an ultrastructural study. Laryngoscope 87: 862871.CrossRefGoogle ScholarPubMed
Seifert, G. (1996) Onkozytäre Karzinome. In: (Seifert, G., ed.). Oralpathologie I, Pathologie der Speicheldrüsen, 2. Aufiage Edition. Springer, Berlin, Heidelberg, New York, pp 625630.Google Scholar
Sikorowa, L. (1957) Oncocytoma malignum. Nowotwory 7: 125131.Google Scholar
Sugimoto, T., Wakizono, S., Uemura, T., Tsuneyoshi, M., Enjoji, M. (1993) Malignant oncocytoma of the parotid gland: a casereport with an immunohistochemical and ultrastructural study. Journal of Laryngology and Otology 107: 6974.CrossRefGoogle Scholar
Tandler, B., Huffer, R. V. P., Erlaredson, R. A. (1970) Ultrastructure of oncocytoma of the parotid gland. Laboratory investigation 23: 567580.Google ScholarPubMed
UJCC. (1987) TNM classification of malignant tumours, 4. (Hermanek, P., Sobin, L. III., eds.). Springer, New York.CrossRefGoogle Scholar
Ziegler, M., Maibach, E. A., Ussmuller, J. (1992) Malignant oncocytoma of the submandibular gland. Laryngo–RhinoOtologie 71: 423425.CrossRefGoogle ScholarPubMed