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Post-transplant lymphoproliferative disorder presenting as epistaxis

Published online by Cambridge University Press:  08 March 2006

Jonathan D. Clarke ,
David Stock  and
Vijay Singh
Jonathan D. Clarke
Affiliation:
Department of Otolaryngology, Royal Glamorgan Hospital, Llantrisant, Wales, UK.
David Stock
Affiliation:
Department of Histopathology, Royal Glamorgan Hospital, Llantrisant, Wales, UK.
Vijay Singh
Affiliation:
Department of Otolaryngology, Royal Glamorgan Hospital, Llantrisant, Wales, UK.
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Abstract

An unusual case of epistaxis resulting from post-transplant lymphoproliferative disorder is described.

A 30-year-old woman who had undergone renal transplantation 12 years previously presented with profuse, posterior, unilateral epistaxis. The initial findings, workup and treatment are presented. A post-nasal space (PNS) mass was detected and biopsy showed this to be an Epstein-Barrvirus-positive polymorphous B-cell post-transplant lymphoproliferative disorder. Computed tomography findings showed a polypoid lesion protruding from the sphenoethmoidal recess and filling the left PNS.

Post-transplant lymphoproliferative disorder is well known to involve tonsil tissue. Commonly, this is the first presentation of the disease in children. However, until now post-transplant lymphoproliferative disorder has not been described in the PNS or nasal cavity presenting as epistaxis. We conclude that all transplant patients presenting with epistaxis should be followed up for an accurate examination of the PNS and nasal cavity after the acute episode.

Keywords

EpistaxisLymphoproliferative Disorder
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 118 , Issue 11 , November 2004 , pp. 906 - 908
Copyright
© 2004 Royal Society of Medicine Press

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