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A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation

Published online by Cambridge University Press:  22 December 2014

A Jain ,
S N Singh ,
P Singhal  and
M P Sharma
A Jain*
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
S N Singh
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
P Singhal
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
M P Sharma
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
*
Address for correspondence: Dr Avani Jain, Flat no C-8, Tower 1, New Moti Bagh, New Delhi 110023, India E-mail: avanijain87@hotmail.com
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Abstract

Background:

Rhabdomyosarcoma is a malignant mesenchymal neoplasm rarely diagnosed in the larynx. Traditionally, it has been treated by radical surgery (i.e. total laryngectomy), followed by radiation and/or chemotherapy. Recent advances suggest that it may be treated with combination therapy comprising high-dose radiation and pulse chemotherapy, with a high success rate.

Case report:

We report the first documented case of subglottic embryonal rhabdomyosarcoma in an adolescent female treated with chemoradiation alone, and review the literature reflecting a move towards organ preservation.

Conclusion:

While surgery has been successfully used to treat this neoplasm, combination therapy, as described in our study, also seems effective and has the added advantage of preserving laryngeal function.

Keywords

RhabdomyosarcomaEmbryonalLarynxChemotherapyRadiotherapy
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 1 , January 2015 , pp. 106 - 109
Copyright
Copyright © JLO (1984) Limited 2014 

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