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True carcinosarcoma of the larynx

Published online by Cambridge University Press:  07 December 2012

M Zhang ,
L-M Zhao ,
X-M Li ,
L Zhou ,
L Lin  and
S-Y Wang
M Zhang
Affiliation:
Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
L-M Zhao
Affiliation:
Department of Otolaryngology, Children's Hospital, Shanghai Jiaotong University, Shanghai, PR China
X-M Li*
Affiliation:
Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
L Zhou
Affiliation:
Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
L Lin
Affiliation:
Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
S-Y Wang
Affiliation:
Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China
*
Address for correspondence: Dr Xiao-ming Li, Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, 83 Fen Yang Road, Shanghai, 200031, PR China Fax: +86 21 64377151 E-mail: ent_zhm@126.com
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Abstract

Objective:

To explore the diagnosis and treatment of carcinosarcoma of the larynx.

Methods:

Clinical information, including presentation, pathology, treatment and outcome, was obtained from a review of patient charts.

Results:

Seven male patients were confirmed pathologically to have had carcinosarcoma between 2003 and 2009 in our hospital. All patients underwent surgery: four total laryngectomies, two vertical partial laryngectomies, and one supracricoid partial laryngectomy-cricohyoidopexy. The mean follow up was 40.6 months. At the time of writing, six patients were alive and being followed; two of these suffered regional metastasis to the cervical lymphatic nodes and underwent radical neck dissection. One patient died of multiple distant metastases 60 months post-operatively.

Conclusion:

Carcinosarcoma of the larynx describes a biphasic tumour showing both carcinomatous and sarcomatous differentiation. It is extraordinarily rare and prone to metastasise to the cervical lymph nodes. Complete surgical resection of laryngeal primary lesions with wide margins and suitable neck dissection of cervical nodes is reasonable therapy.

Keywords

Laryngeal NeoplasmsCarcinosarcomaDiagnosisClinical ProtocolsPathology
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 1 , January 2013 , pp. 100 - 103
Copyright
Copyright © JLO (1984) Limited 2012

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References

1 Luna-Ortiz, K, Mosqueda-Taylor, A. Supracricoid partial laryngectomy as a primary treatment for carcinosarcoma of the larynx. Ear Nose Throat J 2006;85:337–41CrossRefGoogle ScholarPubMed
2 Klijanienko, J, Vielh, P, Duvillard, P, Luboinski, B. True carcinosarcoma of the larynx. J Laryngol Otol 1992;106:58–60 CrossRefGoogle ScholarPubMed
3 Lassaletta, L, Alonso, S, Granell, J, Ballestin, C, Serrano, A, Alvarez-Vincent, JJ. Synchronous glottic granular cell tumour and subglottic spindle cell carcinoma. Arch Otolaryngol Head Neck Surg 1998;124:1031–4CrossRefGoogle ScholarPubMed
4 Alexander, A, Walter, N, Varghese, AM, Mary, L. Pseudosarcoma: a diagnostic and treatment dilemma. J Postgrad Med 2007;53:187–8CrossRefGoogle ScholarPubMed
5 Wick, MR, Swanson, PE. Carcinosarcomas: current perspectives and an historical review of nosological concepts. Semin Diagn Pathol 1993;10:118–27Google Scholar
6 Ernster, JA, Franquemont, DW, Sweeney, JP. Initial report of a case of carcinosarcoma of the supraglottis. Ear Nose Throat J 2000;79:384–7CrossRefGoogle ScholarPubMed
7 Nistal, M, Yébenes-Gregorio, L, Esteban-Rodríguez, I, Bernáldez, R, Regadera, J. Malignant mixed tumour of the larynx. Head Neck 2005;27:166–70CrossRefGoogle Scholar
8 Stomeo, F, Rocca, PC, Bozzo, C, Bianchini, C, Meloni, F, Pastore, A. Laryngeal true malignant mixed tumour. Head Neck 2009;31:556–60CrossRefGoogle Scholar
9 Thompson, LD, Wieneke, JA, Miettinen, M, Heffner, DK. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol 2002;26:153–70CrossRefGoogle ScholarPubMed
10 Ianniello, F, Ferri, E, Armato, E, Longo, L, Zambenedetti, P. Carcinosarcoma of the larynx: immunohistochemical study, clinical considerations, therapeutic strategies [in Italian]. Acta Otorhinolaryngol Ital 2001;21:192–7Google ScholarPubMed
11 Marioni, G, Bottin, R, Staffieri, A, Altavilla, G. Spindle-cell tumours of the larynx: diagnostic pitfalls. A case report and review of the literature. Acta Otolaryngol 2003;123:86–90 CrossRefGoogle ScholarPubMed
12 Ballo, MT, Garden, AS, EI-Naggar, AK, Gillenwater, AM, Morrison, WH, Goepfert, H et al. Radiation therapy for early stage (T1-T2) sarcomatoid carcinoma of true vocal cords: outcomes and patterns of failure. Laryngoscope 1998;108:760–3CrossRefGoogle ScholarPubMed