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Simulating Market Entry Rewards for Antibiotics Development

Published online by Cambridge University Press:  01 January 2021

Extract

We design an agent based Monte Carlo model of antibiotics research and development (R&D) to explore the effects of the policy intervention known as Market Entry Reward (MER) on the likelihood that an antibiotic entering pre-clinical development reaches the market. By means of sensitivity analysis we explore the interaction between the MER and four key parameters: projected net revenues, R&D costs, venture capitalists discount rates, and large pharmaceutical organizations' financial thresholds. We show that improving revenues may be more efficient than reducing costs, and thus confirm that this pull-based policy intervention effectively stimulates antibiotics R&D.

Type
Symposium Articles
Copyright
Copyright © American Society of Law, Medicine and Ethics 2018

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References

Cooper, M. A. and Shlaes, D., “Fix the Antibiotics Pipeline,” Nature 472, no. 7341 (2011): 32; J. O'Neill, “Tackling Drug-Resistant Infections Globally: Final Report and Recommendations,” Review on Antimicrobial Resistance (2016); R. Laxminarayan, A. Duse, C. Wattal, A. K. M. Zaidi, H. F. L Wertheim, N. Sumpradit, E. Vlieghe, G. L. Hara, I. M. Gould, H. Goossens, C. Greko, A. D. So, M. Bigdeli, G. Tomson, W. Woodhouse, E. Ombaka, A.Q. Peralta, F.N. Qamar, F. Mir, S. Kariuki, Z. A. Bhutta, A. Coates, R. Bergstrom, G. D. Wright, E. D. Brown, and O. Cars, “Antibiotic Resistance—the Need for Global Solutions,” The Lancet Infectious Diseases 13, no. 12 (2013): 1057-1098; R. D. Smith and J. Coast, “Antimicrobial Resistance: A Global Response,” Bulletin of the World Health Organization 80, no. 2 (2002): 126-133; M. J. Renwick, D. M. Brogan, and E. Mossialos, “A Systematic Review and Critical Assessment of Incentive Strategies for Discovery and Development of Novel Antibiotics,” Journal of Antibiotics 69, no. 2 (2016): 73-88.Google Scholar
Sertkaya, A., Eyraud, J., Birkenbach, A., Franz, C., Ackerley, N., Overton, V., and Outterson, K., “Analytical Framework for Examining the Value of Antibacterial Products” (2014); A. Towse and P. Sharma, “Incentives for R&D for New Antimicrobial Drugs,” International Journal of the Economics of Business 18, no. 2 (2011): 331350; A. Towse, C. K. Hoyle, J. Goodall, M. Hirsch, J. Mestre-Ferrandiz, and J. H. Rex, “Time for a Change in How New Antibiotics Are Reimbursed: Development of an Insurance Framework for Funding New Antibiotics Based on a Policy of Risk Mitigation,” Health Policy 121, no. 10 (2017): 1025-1030.Google Scholar
Dawid, H. and Neugart, M., “Agent-Based Models for Economic Policy Design,” Eastern Economic Journal 37 (2011): 4450.CrossRefGoogle Scholar
See Towse and Sharma, supra note 2.Google Scholar
See Sertkaya, supra note 2.Google Scholar
Grace, C. and Kyle, M., “Comparative Advantages of Push and Pull Incentives for Technology Development: Lessons for Neglected Disease Technology Development,” Global Forum Update on Research for Health 6 (2009): 147151.Google Scholar
Rex, J. H. and Outterson, K., “Antibiotic Reimbursement in a Model Delinked from Sales: A Benchmark-Based Worldwide Approach,” The Lancet Infectious Diseases 16, no. 4 (2016): 500505.CrossRefGoogle Scholar
Blau, G. E., Pekny, J. F., Varma, V. A., and Bunch, P. R., “Managing a Portfolio of Interdependent New Product Candidates in the Pharmaceutical Industry,” Journal of Product Innovation Management 21, no. 4 (2004): 227245; C. Okhravi, S. McK-eever, C. Kronlid, E. Baraldi, O. Lindahl, and F. Ciabuschi, d“Simulating Market-Oriented Policy Interventions for Stimulating Antibiotics Development,” Proceedings of the 50th Annual Simulation Symposium (2017).Google Scholar
See Blau, supra note 8.Google Scholar
See Sertkaya, supra note 2.Google Scholar
Katz, M. L., Mueller, L. V., Polyakov, M., and Weinstock, S. F., “Where Have All the Antibiotic Patents Gone?” Nature Bio-technology 24, no. 12 (2006): 15291531; D. J. Payne, L. F. Miller, D. Findlay, J. Anderson, and L. Marks, “Time for a Change: Addressing R&D and Commercialization Challenges for Antibacterials,” Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1670 (2015); A. Zorzet, “Overcoming Scientific and Structural Bottlenecks in Antibacterial Discovery and Development,” Upsala Journal of Medical Sciences 119, no. 2 (2014): 170-175.Google Scholar