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In vivo performance analysis of silanized and coated nitinol wires in biological environment

Published online by Cambridge University Press:  19 May 2020

Sarmita Sinha ,
Jyotsana Priyadarshani ,
Karuppasamy Bavya Devi ,
Anyam Vijay Kishore ,
Piyali Das ,
Abhijit Chanda ,
Soumen Das ,
Mangal Roy  and
Samit Kumar Nandi
Sarmita Sinha
Affiliation:
Department of Mechanical Engineering, Jadavpur University, Kolkata 700032, India
Jyotsana Priyadarshani
Affiliation:
School of Medical Science and Technology, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India
Karuppasamy Bavya Devi
Affiliation:
Department of Metallurgical and Materials Engineering, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India
Anyam Vijay Kishore
Affiliation:
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India
Piyali Das
Affiliation:
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India
Abhijit Chanda*
Affiliation:
Department of Mechanical Engineering, Jadavpur University, Kolkata 700032, India
Soumen Das
Affiliation:
School of Medical Science and Technology, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India
Mangal Roy
Affiliation:
Department of Metallurgical and Materials Engineering, Indian Institute of Technology-Kharagpur, Kharagpur 721302, India
Samit Kumar Nandi*
Affiliation:
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India
*
a)Address all correspondence to these authors. e-mail: abhijitchanda.biomed@gmail.com
b)e-mail: samitnandi1967@gmail.com
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Abstract

Some interesting properties such as superelasticity, shape memory effect, kink resistance, good biocompatibility, biomechanical properties, and corrosion resistance made nitinol a popular biomaterial as stent and orthopedic implants. But surface modification is needed to control nickel leaching from its surface, making safe for human body. The aim of this study was to modify the nitinol surface by the silanization technique and electrophoretically deposited hydroxyapatite coating, and to conduct a detailed in vitro and in vivo investigation. Detailed in vitro investigation involved MTT assay with the human osteoblastic cells (MG63 cell) over a period of 5 days and confocal image study. In case of in vivo study, histological study, fluorochrome labeling study, and Micro-Ct study were conducted. The overall in vitro and in vivo results indicate that silanized nitinol samples are showing slightly better level of performance, but both the surface-modified samples are suitable as the potential bio-implant for orthopedic purpose.

Keywords

surface modificationmicro-CTelectrophoretic deposition
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 10 , 28 May 2020 , pp. 1262 - 1270
Copyright
Copyright © Materials Research Society 2020

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Footnotes

c)

Present address: Department of Chemistry, Nims Institute of Engineering & Technology, Nims University Rajasthan, Jaipur-Delhi Highway (NH-11C), Nims Institute of Engineering & Technology, Jaipur-303121, Rajasthan, India.

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