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A multifunctional poly(acrylic acid)/gelatin hydrogel

Published online by Cambridge University Press:  31 January 2011

Qunwei Tang ,
Jihuai Wu ,
Jianming Lin ,
Shijun Fan  and
De Hu
Jihuai Wu*
Affiliation:
The Key Laboratory for Functional Materials of Fujian Higher Education Institute of Materials Physical Chemistry, Huaqiao University, Quanzhou, 362021, China
De Hu
Affiliation:
The Key Laboratory for Functional Materials of Fujian Higher Education Institute of Materials Physical Chemistry, Huaqiao University, Quanzhou, 362021, China
*
a) Address all correspondence to this author. e-mail: jhwu@hqu.edu.cn
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Abstract

A poly(acrylic acid)/gelatin interpenetrating network hydrogel was synthesized by aqueous solution polymerization. The influences of preparation conditions including cross-linker, initiator, gelatin content, and neutralization degree on the swelling ratios of the hydrogels are investigated. The swelling, mechanical strength, biodegradability, and drug-release properties of poly(acrylic acid)/gelatin hydrogel are evaluated. The hydrogel has excellent mechanical properties; tensile strength is 1500 kPa, and elongation at break is 887%, respectively. The in vitro biodegradation shows that an interpenetrating network structure exists in the poly(acrylic acid)/gelatin hybrid hydrogel. A release study indicates that the theophylline release from the hydrogel depends on the cross-linking density of the hydrogel and pH of the medium, and the drug diffusion obeys an anomalous transport model.

Keywords

AdsorptionBiomaterialPolymerization
Type
Articles
Information
Journal of Materials Research , Volume 24 , Issue 5 , May 2009 , pp. 1653 - 1661
Copyright
Copyright © Materials Research Society 2009

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References

REFERENCES

1.Omidian, H., Rocca, J.G., and Park, K.: Advances in superporous hydrogels. J. Controlled Release 102, 3 (2005).CrossRefGoogle ScholarPubMed
2.Geever, L.M., Devine, D.M., Nugent, M.J.D., Kennedy, J.E., Lyons, J.G., and Higginbotham, C.L.: The synthesis, characterisation, phase behaviour and swelling of temperature sensitive physically crosslinked poly(1-vinyl-2-pyrrolidinone)/poly(N-isopropylacrylamide) hydrogels. Eur. Polym. J. 42, 69 (2006).CrossRefGoogle Scholar
3.Coughlan, D.C. and Corrigan, O.I.: Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems. Int. J. Pharm. 313, 163 (2006).CrossRefGoogle ScholarPubMed
4.Rodriguez, D.E., Romero-Garcia, J., Ramirez-Vargas, E., and Arias-Marin, E.: Synthesis and swelling characteristics of semi-interpenetrating polymer network hydrogels composed of poly (acrylamide) and poly(γ-glutamic acid). Mater. Lett. 60, 1390 (2006).CrossRefGoogle Scholar
5.Tang, Q.W., Lin, J.M., Wu, J.H., Zhang, C.J., and Hao, S.C.: Two-steps synthesis of a poly(acrylate–aniline) conducting hydrogel with an interpenetrated networks structure. Carbohyd. Polum. 67, 332 (2007).CrossRefGoogle Scholar
6.Chen, F.M., Zhao, Y.M., Wu, H., Deng, Z.H., Wang, Q.T., and Zhou, W.: Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran–co-gelatin microspheres. J. Control. Release 114, 209 (2006).CrossRefGoogle ScholarPubMed
7.Hori, K., Sotozono, C., Hamuro, J., Yamasaki, K., Kimura, Y., and Ozeki, M.: Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing. J. Control. Release 118, 169 (2007).CrossRefGoogle ScholarPubMed
8.Tabata, Y. and Ikada, Y.: Protein release from gelatin matrices. Adv. Drug Delivery Rev. 31, 287 (1998).CrossRefGoogle Scholar
9.Tabata, Y. and Ikada, Y.: Vascularization effect of basic fibroblast growth-factor released from gelatin hydrogels with different bio-degradabilities. Biomaterials 20, 2169 (1999).CrossRefGoogle Scholar
10.Iwakura, A., Tabata, Y., and Koyama, T.: Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries. J. Thorac. Cardiovasc. Surg. 126, 1113 (2003).CrossRefGoogle ScholarPubMed
11.Nakano, T., Kaibara, K., Tabata, Y., Nagata, N., Enomoto, S., and Marukawa, E.: Unique alignment and texture of biological apatite crystallites in typical calcified tissues analyzed by microbeam x-ray diffractometer system. Bone 31, 479 (2002).CrossRefGoogle ScholarPubMed
12.Kimura, Y., Ozeki, M., Inamoto, T., and Tabata, Y.: Adipose tissue engineering based on human preadipocytes combined with gelatin microspheres containing basic fibroblast growth factor. Biomaterials 24, 2513 (2003).CrossRefGoogle ScholarPubMed
13.Karadag, E., Uzum, O.B., Saraydin, D., and Guven, O.: Dynamic swelling behavior of γ-radiation induced polyelectrolyte poly (AAm-co-CA) hydrogels in urea solutions. Int. J. Pharm. 301, 102 (2005).CrossRefGoogle ScholarPubMed
14.Tao, Y., Zhao, J.X., and Wu, C.X.: Polyacrylamide hydrogels with trapped sulfonated polyaniline. Eur. Polym. J. 41, 1342 (2005).CrossRefGoogle Scholar
15.Chiu, H., Hsiue, T., and Chen, W.: FTIR-ATR measurements of the ionization extent of acrylic acid within copolymerized methacry-lated dextran/acrylic acid networks and its relation with pH/salt concentration-induced equilibrium swelling. Polymer (Guildf.). 45, 1627 (2004).CrossRefGoogle Scholar
16.Chen, Z.B., Liu, M.Z., and Ma, S.M.: Synthesis and modification of salt-resistant superabsorbent polymers. React. Funct. Polym. 62, 85 (2005).CrossRefGoogle Scholar
17.Pourjavadi, A., Barzegar, S.H., and Mahdavinia, G.R.: MBA-crosslinked Na-Alg/CMC as a smart full-polysaccharide superabsorbent hydrogels. Carbohydr. Polym. 66, 386 (2006).CrossRefGoogle Scholar
18.Tang, Q.W., Wu, J.H., Lin, J.M., Sun, H., Ao, H.Y.: A high mechanical strength hydrogel from polyacrylamide/polyacrylamide with interpenetrating network structure by two-steps synthesis method. e-Polymers 21, 1 (2008).Google Scholar
19.Serra, L., Domenech, J., and Peppas, N.A.: Drug transport mechanisms and release kinetics from molecularly designed poly(acrylic acid-g-ethylene glycol) hydrogels. Biomaterials 27, 5440 (2006).CrossRefGoogle ScholarPubMed
20.Changez, M., Koul, V., Krishna, B., and Choudhary, V.: Studies on biodegradation and release of gentamicin sulphate from interpenetrating network hydrogels based on poly(acrylic acid) and gelatin: In vitro and in vivo. Biomaterials 25, 139 (2004).CrossRefGoogle ScholarPubMed
21.Yang, Z.W., Jiang, Y.S., Xu, L.X., Wen, B., Li, F.F., Sun, S.M., and Hou, T.Y.: Preparation and characterization of magnesium doped hydroxyapatitegelatin nanocomposite. J. Mater. Chem. 15, 1807 (2005).CrossRefGoogle Scholar
22.Wu, J.H., Wei, Y.L., Lin, J.M., and Lin, S.B.: Study on starch-graft-acrylamide/mineral powder superabsorbent composite. Polymer (Guildf.). 44, 6513 (2003).CrossRefGoogle Scholar
23.Li, A. and Wang, A.: Synthesis and properties of clay-based super-absorbent composite. Eur. Polym. J. 41, 1630 (2005).CrossRefGoogle Scholar
24.Wu, J.H., Lin, J.M., Li, G.Q., and Wei, C.R.: Influence of the COOH and COONa groups and crosslink density of poly(acrylic acid)/montmorillonite superabsorbent composite on water absor-bency. Polym. Int. 50, 1050 (2001).CrossRefGoogle Scholar
25.Wu, J.H., Wei, Y.L., Lin, J.M., and Lin, S.B.: Preparation of a starch-graft-acrylamide/kaolinite superabsorbent composite and the influence of the hydrophilic group on its water absorbency. Polym. Int. 52, 1909 (2003).CrossRefGoogle Scholar
26.Pourjavadi, A., Barzegar, S.H., and Zeidabadi, F.: Synthesis and properties of biodegradable hydrogels of κ-carrageenan grafted acrylic acid-co-2-acrylamido-2-methylpropanesulfonic acid as candidates for drug delivery systems. React. Fund. Polym. 67, 644 (2007).CrossRefGoogle Scholar
27.Tsukeshiba, H., Huang, M., Na, Y.H., and Tanaka, Y.: Effect of polymer entanglement on the toughening of double network hydrogels. J. Phys. Chem. B 109, 16304 (2005).CrossRefGoogle ScholarPubMed
28.Na, Y.H., Kurokawa, T., and Tsukeshiba, H.: Structural characteristics of double network gels with extremely high mechanical strength. Macromolecules 37, 5370 (2004).CrossRefGoogle Scholar
29.Jia, X.Q., Burdick, J.A., Kobler, J., Clifton, R.J., Rosowski, J.J., and Zeitel, S.M.: Synthesis and characterization of in situ cross-linkable hyaluronic acid-based hydrogels with potential application for vocal fold regeneration. Macromolecules 37, 3239 (2004).CrossRefGoogle Scholar
30.Ferry, J.D.: Viscoelastic Properties of Polymers, 3rd ed. (Wiley, New York, 1980).Google Scholar
31.Bird, R.B., Armstrong, R.C., and Hassager, O.: Dynamics of Polymeric Liquids, (Wiley, New York, 1977), p. 129.Google Scholar
32.Stephens, D., Kli, L., Robinson, D., Chen, S., Chang, H.C., Liu, R.M., Tian, Y., Ginsburg, E.J., Gao, X., and Stultz, T.: Investigation of the in vitro release of gentamicin from a poly anhydride matrix. J. Control. Release 63, 305 (2000).CrossRefGoogle Scholar
33.Ritger, P.L. and Peppas, N.A.: A simple equation for description of solute release. I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. J. Control. Release 5, 23 (1987).CrossRefGoogle Scholar