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A Clinical Trial of Deserpidine and Reserpine in the Treatment of the Chronic Schizophrenic

Published online by Cambridge University Press:  08 February 2018

G. A. Dransfield  and
M. W. Browne
G. A. Dransfield
Affiliation:
Warley Hospital, Brentwood, Essex
M. W. Browne
Affiliation:
Department of Psychological Medicine, University College Hospital, W.C.1
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Extract

Recent work, such as that of Moore and Martin (1957), has shown that reserpine is of value in the treatment of the chronic schizophrenic patient. Attention has however been drawn to the incidence of side-effects in this form of treatment. These side-effects have limited the application of the drug and have also led to the search for a related substance, of similar clinical effect but without the troublesome toxic effects. This present trial is of a substance, deserpidine (Harmonyl, Abbott Laboratories), which it was thought would fulfil these requirements. The isolation of this alkaloid was first reported in 1955 by Stoll and Hofman, and it has subsequently been identified as 11-desmethoxy-reserpine (Harrisson, 1955) which can be represented thus:

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 441 , October 1959 , pp. 1112 - 1118
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

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