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Apathy Is Related to Cognitive Control and Striatum Volumes in Prodromal Huntington’s Disease

Published online by Cambridge University Press:  26 February 2019

Maria B. Misiura ,
Jennifer Ciarochi ,
Jatin Vaidya ,
Jeremy Bockholt ,
Hans J. Johnson ,
Vince D. Calhoun ,
Jane S. Paulsen ,
Jessica A. Turner  and
the PREDICT-HD Investigators & Working Group
Maria B. Misiura*
Affiliation:
Department of Psychology, Georgia State University, Atlanta, Georgia
Jennifer Ciarochi
Affiliation:
Neuroscience Institute, Georgia State University, Atlanta, Georgia
Jatin Vaidya
Affiliation:
University of Iowa Carver College of Medicine, Iowa City, Iowa
Jeremy Bockholt
Affiliation:
University of Iowa Carver College of Medicine, Iowa City, Iowa The Mind Research Network, Albuquerque, New Mexico
Hans J. Johnson
Affiliation:
University of Iowa Carver College of Medicine, Iowa City, Iowa Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa
Vince D. Calhoun
Affiliation:
Department of Psychology, Georgia State University, Atlanta, Georgia Neuroscience Institute, Georgia State University, Atlanta, Georgia The Mind Research Network, Albuquerque, New Mexico Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, New Mexico
Jane S. Paulsen
Affiliation:
University of Iowa Carver College of Medicine, Iowa City, Iowa
Jessica A. Turner
Affiliation:
Department of Psychology, Georgia State University, Atlanta, Georgia Neuroscience Institute, Georgia State University, Atlanta, Georgia
the PREDICT-HD Investigators & Working Group
Affiliation:
Department of Psychology, Georgia State University, Atlanta, Georgia Neuroscience Institute, Georgia State University, Atlanta, Georgia University of Iowa Carver College of Medicine, Iowa City, Iowa The Mind Research Network, Albuquerque, New Mexico Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, New Mexico Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa
*
Correspondence and reprint requests to: Maria B. Misiura, Department of Psychology Georgia State University P.O. Box 5010 Atlanta, GA 30302. Email: mariamisiura@gmail.com
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Abstract

Objectives: Apathy is a debilitating symptom of Huntington’s disease (HD) and manifests before motor diagnosis, making it an excellent therapeutic target in the preclinical phase of Huntington’s disease (prHD). HD is a neurological genetic disorder characterized by cognitive and motor impairment, and psychiatric abnormalities. Apathy is not well characterized within the prHD. In previous literature, damage to the caudate and putamen has been correlated with increased apathy in other neurodegenerative and movement disorders. The objective of this study was to determine whether apathy severity in individuals with prHD is related to striatum volumes and cognitive control. We hypothesized that, within prHD individuals, striatum volumes and cognitive control scores would be related to apathy. Methods: We constructed linear mixed models to analyze striatum volumes and cognitive control, a composite measure that includes tasks assessing with apathy scores from 797 prHD participants. The outcome variable for each model was apathy, and the independent variables for the four separate models were caudate volume, putamen volume, cognitive control score, and motor symptom score. We also included depression as a covariate to ensure that our results were not solely related to mood. Results: Caudate and putamen volumes, as well as measures of cognitive control, were significantly related to apathy scores even after controlling for depression. Conclusions: The behavioral apathy expressed by these individuals was related to regions of the brain commonly associated with isolated apathy, and not a direct result of mood symptoms. (JINS, 2019, 25, 462–469)

Keywords

ApathyHuntington diseaseExecutive functionCaudatePutamenBasal ganglia diseases
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 25 , Issue 5 , May 2019 , pp. 462 - 469
Copyright
Copyright © The International Neuropsychological Society 2019 

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Footnotes

*

Jane S. Paulsen and Jessica A. Turner are Senior Authors

References

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