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Everyday Action Impairment in Parkinson's Disease Dementia

Published online by Cambridge University Press:  24 May 2012

Tania Giovannetti ,
Priscilla Britnell ,
Laura Brennan ,
Andrew Siderowf ,
Murray Grossman ,
David J. Libon ,
Brianne M. Bettcher ,
Francesca Rouzard ,
Joel Eppig  and
Gregory A. Seidel
Tania Giovannetti*
Affiliation:
Department of Psychology, Temple University, Philadelphia, Pennsylvania
Priscilla Britnell
Affiliation:
Department of Psychology, Temple University, Philadelphia, Pennsylvania
Laura Brennan
Affiliation:
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Andrew Siderowf
Affiliation:
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Murray Grossman
Affiliation:
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
David J. Libon
Affiliation:
Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania
Brianne M. Bettcher
Affiliation:
Memory and Aging Center, University of California San Francisco, San Francisco, California
Francesca Rouzard
Affiliation:
Department of Psychology, Temple University, Philadelphia, Pennsylvania
Joel Eppig
Affiliation:
Department of Psychology, Temple University, Philadelphia, Pennsylvania
Gregory A. Seidel
Affiliation:
Department of Psychology, Temple University, Philadelphia, Pennsylvania
*
Correspondence and reprint requests to: Tania Giovannetti, Temple University, Psychology Department, 1701 N. 13th Street, Philadelphia, PA 19122, USA. E-mail: tgio@temple.edu
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Abstract

This study examined everyday action impairment in participants with Parkinson's disease dementia (PDD) by comparison with participants with Parkinson's disease-no dementia (PD) or Alzheimer's disease (AD) and in reference to a neuropsychological model. Participants with PDD (n = 20), PD (n = 20), or AD (n = 20) were administered performance-based measures of everyday functioning that allowed for the quantification of overall performance and error types. Also, caregiver ratings of functional independence were obtained. On performance-based tests, the PDD group exhibited greater functional impairment than the PD group but comparable overall impairment relative to the AD group. Error patterns did not differ between PDD and PD participants but the PDD group demonstrated a higher proportion of commission errors and lower proportion of omission errors relative to the AD group. Hierarchical regression analyses showed omission errors were significantly predicted by neuropsychological measures of episodic memory, whereas commission errors were predicted by both measures of general dementia severity (MMSE) and executive control. Everyday action impairment in PDD differs quantitatively from PD but qualitatively from AD and may be characterized by a relatively high proportion of commission errors—an error type associated with executive control deficits. (JINS, 2012, 18, 1–12)

Keywords

Naturalistic actionActivities of daily livingDementiaFunctional abilitiesIdeational apraxiaInstrumental activities of daily livingExecutive functionsEpisodic memory
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 5 , September 2012 , pp. 787 - 798
Copyright
Copyright © The International Neuropsychological Society 2012

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