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Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum

Published online by Cambridge University Press:  22 March 2021

Ryan W. Mangum ,
Justin S. Miller ,
Warren S. Brown Open the ORCID record for Warren S. Brown [Opens in a new window] ,
Anne A.T. Nolty Open the ORCID record for Anne A.T. Nolty [Opens in a new window]  and
Lynn K. Paul Open the ORCID record for Lynn K. Paul [Opens in a new window]
Ryan W. Mangum
Affiliation:
Fuller Graduate School of Psychology, Travis Research Institute, Pasadena, CA, USA
Justin S. Miller
Affiliation:
Fuller Graduate School of Psychology, Travis Research Institute, Pasadena, CA, USA
Warren S. Brown
Affiliation:
Fuller Graduate School of Psychology, Travis Research Institute, Pasadena, CA, USA International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5), Pasadena, CA, USA
Anne A.T. Nolty
Affiliation:
Fuller Graduate School of Psychology, Travis Research Institute, Pasadena, CA, USA
Lynn K. Paul*
Affiliation:
Fuller Graduate School of Psychology, Travis Research Institute, Pasadena, CA, USA International Research Consortium for the Corpus Callosum and Cerebral Connectivity (IRC5), Pasadena, CA, USA California Institute of Technology, Division of Humanities and Social Sciences, Pasadena, CA, USA
*
*Correspondence and reprint requests to: Lynn K. Paul, Baxter MC 228-77, California Institute of Technology, 1200 E California Blvd, Pasadena, CA91125, USA. E-mail: lkpaul@hss.caltech.edu
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Abstract

Objective:

Agenesis of the corpus callosum (AgCC) is associated with a range of cognitive deficits, including mild to moderate problems in higher order executive functions evident in neuropsychological assessments. Previous research has also suggested a lack of self-awareness in persons with AgCC.

Method:

We investigated daily executive functioning and self-awareness in 36 individuals with AgCC by analyzing self-ratings on the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), as well as ratings on the same instrument from close relatives. Discrepancies between self- and informant-ratings were compared to the normative sample and exploratory analyses examined possible moderating effects of participant and informant characteristics.

Results:

Significant deficiencies were found in the Behavioral Regulation and Metacognitive indices for both the self and informant results, with elevated frequency of metacognition scores in the borderline to clinical range. Informants also endorsed elevated frequency of borderline to clinically significant behavioral regulation scores. The proportion of AgCC participants whose self-ratings indicated less metacognitive impairment than informant-ratings was greater than in the normative sample. Self-ratings of behavioral regulation impairment decreased with age and informant-ratings of metacognition were higher in males than females.

Conclusions:

These findings provide evidence that individuals with AgCC experience mild to moderate executive functioning problems in everyday behavior which are observed by others. Results also suggest a lack of self-understanding or insight into the severity of these problems in the individuals with AgCC, particularly with respect to their metacognitive functioning.

Keywords

Behavioral regulationcognitive flexibilityexecutive functionmetacognitionself-awarenessinterhemispheric commissureBRIEF-A
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 10 , November 2021 , pp. 1037 - 1047
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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