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How Functional Connectivity between Emotion Regulation Structures Can Be Disrupted: Preliminary Evidence from Adolescents with Moderate to Severe Traumatic Brain Injury

Published online by Cambridge University Press:  28 August 2013

Mary R. Newsome ,
Randall S. Scheibel ,
Andrew R. Mayer ,
Zili D. Chu ,
Elisabeth A. Wilde ,
Gerri Hanten ,
Joel L. Steinberg ,
Xiaodi Lin ,
Xiaoqi Li  and
Tricia L. Merkley
...Show all authors
Mary R. Newsome*
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Randall S. Scheibel
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Andrew R. Mayer
Affiliation:
The Mind Research Network, Albuquerque, New Mexico Neurology Department, University of New Mexico School of Medicine, Albuquerque, New Mexico
Zili D. Chu
Affiliation:
Department of Radiology, Baylor College of Medicine, Houston, Texas Department of Pediatric Radiology, Texas Children's Hospital, Houston, Texas
Elisabeth A. Wilde
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas Department of Radiology, Baylor College of Medicine, Houston, Texas Department of Neurology, Baylor College of Medicine, Houston, Texas
Gerri Hanten
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Joel L. Steinberg
Affiliation:
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia
Xiaodi Lin
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Xiaoqi Li
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Tricia L. Merkley
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas Department of Psychology, Brigham Young University, Provo, Utah
Jill V. Hunter
Affiliation:
Department of Radiology, Baylor College of Medicine, Houston, Texas Department of Pediatric Radiology, Texas Children's Hospital, Houston, Texas
Ana C. Vasquez
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
Lori Cook
Affiliation:
Center for Brain Health, University of Texas at Dallas, Dallas, Texas
Hanzhang Lu
Affiliation:
Advanced Imaging Research Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
Kami Vinton
Affiliation:
Center for Brain Health, University of Texas at Dallas, Dallas, Texas
Harvey S. Levin
Affiliation:
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas Department of Neurology, Baylor College of Medicine, Houston, Texas Department of Neurosurgery, Baylor College of Medicine, Houston, Texas
*
Correspondence and reprint requests to: Mary R. Newsome, Cognitive Neuroscience Laboratory Baylor College of Medicine, 1709 Dryden Road, Ste 12.59, Houston, TX 77030. E-mail: mnewsome@bcm.edu
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Abstract

Outcome of moderate to severe traumatic brain injury (TBI) includes impaired emotion regulation. Emotion regulation has been associated with amygdala and rostral anterior cingulate (rACC). However, functional connectivity between the two structures after injury has not been reported. A preliminary examination of functional connectivity of rACC and right amygdala was conducted in adolescents 2 to 3 years after moderate to severe TBI and in typically developing (TD) control adolescents, with the hypothesis that the TBI adolescents would demonstrate altered functional connectivity in the two regions. Functional connectivity was determined by correlating fluctuations in the blood oxygen level dependent (BOLD) signal of the rACC and right amygdala with that of other brain regions. In the TBI adolescents, the rACC was found to be significantly less functionally connected to medial prefrontal cortices and to right temporal regions near the amygdala (height threshold T = 2.5, cluster level p < .05, FDR corrected), while the right amygdala showed a trend in reduced functional connectivity with the rACC (height threshold T = 2.5, cluster level p = .06, FDR corrected). Data suggest disrupted functional connectivity in emotion regulation regions. Limitations include small sample sizes. Studies with larger sample sizes are necessary to characterize the persistent neural damage resulting from moderate to severe TBI during development. (JINS, 2013, 19, 1–14)

Keywords

Resting statefMRIAdolescentsEmpathyTBIAnterior cingulate
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 8 , September 2013 , pp. 911 - 924
Copyright
Copyright © The International Neuropsychological Society 2013 

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