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A large-scale retrospective study of closing-in behavior in Alzheimer’s disease

Published online by Cambridge University Press:  01 September 2009

ELISABETTA AMBRON ,
ROBERT D. MCINTOSH ,
FRANCESCA ALLARIA  and
SERGIO DELLA SALA
ELISABETTA AMBRON
Affiliation:
Department of Psychology, Human Cognitive Neuroscience, University of Edinburgh, Edinburgh, United Kingdom Laboratory of Experimental Psychology, Suor Orsola Benincasa University, Naples, Italy
ROBERT D. MCINTOSH*
Affiliation:
Department of Psychology, Human Cognitive Neuroscience, University of Edinburgh, Edinburgh, United Kingdom
FRANCESCA ALLARIA
Affiliation:
Third Neurological Department, University of Milan, St. Paolo Hospital, Milan, Italy
SERGIO DELLA SALA
Affiliation:
Department of Psychology, Human Cognitive Neuroscience, University of Edinburgh, Edinburgh, United Kingdom Department of Psychology, Center for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
*
*Correspondence and reprint requests to: Robert D. McIntosh, Human Cognitive Neuroscience, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ. E-mail: r.d.mcintosh@ed.ac.uk
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Abstract

The frequency and characteristics of closing-in behavior (CIB) were examined in 797 patients with Alzheimer’s disease (AD), 132 of whom were followed up longitudinally. The frequency of CIB increased with the complexity of the graphic copying task and with the severity of Alzheimer’s disease. Regression analyses suggested that attentional deficits are critical factors for the appearance of CIB, but that visuospatial impairments also play an important role in the emergence of severe forms of CIB. (JINS, 2009, 15, 787–792.)

Keywords

Constructional apraxiaDementiaAttentionExecutive functionsVisuospatial abilitiesDrawing
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 5 , September 2009 , pp. 787 - 792
Copyright
Copyright © The International Neuropsychological Society 2009

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References

REFERENCES

Ambron, E., Allaria, F., McIntosh, R.D., & Della Sala, S. (2009a). Closing-in behaviour in fronto-temporal dementia. Journal of Neurology epub Feb 25 2009.CrossRefGoogle ScholarPubMed
Ambron, E., McIntosh, R.D., & Della Sala, S. (2009b). Animal magnetism: Evidence for an attraction account of closing-in behaviour in pre-school children. Cortex, 45, 278–284.CrossRefGoogle ScholarPubMed
Brazzelli, E., Capitani, E., Della Sala, S., Spinnler, H., & Zuffi, M. (1994). A neuropsychological instrument adding to the description of patients with suspected cortical dementia: The Milan overall dementia assessment. Journal of Neurology, Neurosurgery and Psychiatry, 57, 1510–1517.CrossRefGoogle Scholar
Conson, M., Salzano, S., Manzo, V., Grossi, D., & Trojano, L. (2009). Closing-in without severe drawing disorders: The “fatal” consequences of pathological attraction. Cortex, 45, 285–292.CrossRefGoogle ScholarPubMed
Critchley, M. (1953). Constructional apraxia. In: Butler & Tanner Ltd. (Eds.), The parietal lobes. London: Edward Arnold.Google Scholar
De Ajuriaguerra, J., Muller, M., & Tissot, R. (1960). A propos de quelque problémes posés par l’apraxie dans les démences. Encephale, 49, 375–401.Google Scholar
Della Sala, S., Laiacona, M., Spinnler, H., & Ubezio, C. (1992). A cancellation test: Its reliability in assessing attentional deficits in Alzheimer’s disease. Psychological Medicine, 22, 885–901.CrossRefGoogle ScholarPubMed
Gainotti, G., (1972). A qualitative study of the closing-in symptom in normal children and in brain-damaged patients. Neuropsychologia, 10, 429–436.CrossRefGoogle Scholar
Gainotti, G., Parlato, V., Monteleone, D., & Carlomagno, S. (1992). Neuropsychological markers of dementia on visual-spatial tasks: A comparison between Alzheimer’s type and vascular forms of dementia. Journal of Clinical and Experimental Neuropsychology, 14, 239–252.CrossRefGoogle ScholarPubMed
Grossi, D., Orsini, A., & De Michele, G. (1978). The copying of geometric drawings in dementia: An experimental study of 218 subjects. Acta Neurologica (Napoli), 18, 355–360.Google Scholar
Kwak, Y.T. (2004). Closing-in phenomenon in Alzheimer’s disease and subcortical vascular dementia. BioMed Central Neurology, 4, 1–7.Google ScholarPubMed
Kwon, J.C., Kang, S.J., Lee, B.H., Chin, J., Heilman, K.M., & Na, D.L. (2002). Manual approach during hand gesture imitation. Archives of Neurology, 59, 1468–1475.CrossRefGoogle ScholarPubMed
Lee, B.H., Chin, J., Kang, S.J., Kim, E.J., Park, K.C., & Na, D.L. (2004). Mechanism of the closing-in phenomenon in a figure coping task in Alzheimer’s disease patients. Neurocase, 10, 393–397.CrossRefGoogle Scholar
Mayer Gross, W. (1935). Some observations on apraxia. Proceedings of the Royal Society of Medicine, 28, 63–72.Google ScholarPubMed
McIntosh, R.D., Ambron, E., & Della Sala, S. (2008). Evidence for an attraction account of closing-in behaviour. Cognitive Neuropsychology, 25, 376–394.CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzeimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939–944.CrossRefGoogle Scholar
Ober, B.A., Jagust, W.J., Koss, E., Delis, D.C., & Friedland, R.P. (1991). Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer’s disease. Journal of Clinical and Experimental Neuropsychology, 13, 752–772.CrossRefGoogle ScholarPubMed
Spinnler, H. (1991). The role of attention disorders in the cognitive breakdown of dementia. In: Boller, F. & Grafman, J. (Eds.), Handbook of neuropsychology. Amsterdam: Elsevier.Google Scholar
Spinnler, H., & Della Sala, S. (1988). The role of clinical neuropsychology in the neurological diagnosis of Alzheimer’s disease. Journal of Neurology, 235, 258–271.CrossRefGoogle ScholarPubMed
Trojano, L., Grossi, D., & Flash, T. (2009). Cognitive neuroscience of drawing: Contributions of neuropsychological, experimental and neurofunctional studies. Cortex, 45, 269–277.CrossRefGoogle ScholarPubMed