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Aerobic Fitness Level Moderates the Association Between Cannabis Use and Executive Functioning and Psychomotor Speed Following Abstinence in Adolescents and Young Adults

Published online by Cambridge University Press:  26 November 2018

Natasha E. Wade ,
Alexander L. Wallace ,
Ann M. Swartz  and
Krista M. Lisdahl
Natasha E. Wade
Affiliation:
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin
Alexander L. Wallace
Affiliation:
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin
Ann M. Swartz
Affiliation:
Department of Kinesiology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin
Krista M. Lisdahl*
Affiliation:
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin
*
Correspondence and reprint requests to: Krista M. Lisdahl, 2441 East Hartford Avenue, Milwaukee, WI 53211. E-mail: krista.medina@gmail.com
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Abstract

Objectives: The high rate of cannabis (CAN) use in emerging adults is concerning given prior research suggesting neurocognitive deficits associated with CAN use in youth. Regular CAN use downregulates endocannabinoid activity, while aerobic exercise upregulates cannabinoid receptor 1 activity and releases endocannabinoids. Here we investigate the influence of regular CAN use on neuropsychological performance, and whether aerobic fitness moderates these effects. Methods: Seventy-nine young adults (37 CAN users) aged 16–26 participated. Groups were balanced for aerobic fitness level. Exclusion criteria included: left-handedness, past-year independent Axis-I disorders, major medical/neurologic disorders, prenatal issues, or prenatal alcohol/illicit drug exposure. After 3 weeks of abstinence, participants completed a neuropsychological battery and a maximal oxygen consumption test (VO2 max). Multiple regressions tested whether past-year CAN use, VO2 max, and CAN*VO2 max interaction predicted neuropsychological performance, controlling for past-year alcohol use, cotinine, gender, and depression symptoms. Results: Increased CAN use was associated with decreased performance on working memory and psychomotor tasks. High aerobic fitness level was related to better performance on visual memory, verbal fluency, and sequencing ability. CAN*VO2 max predicted performance of psychomotor speed, visual memory, and sequencing ability. Conclusions: Following monitored abstinence, increased CAN use was associated with poorer performance in working memory and psychomotor speed. Higher aerobic fitness level moderated the impact of CAN on visual memory, executive function and psychomotor speed, as more aerobically fit CAN users demonstrated better performance relative to low-fit users. Therefore, aerobic fitness may present an affordable and efficacious method to improve cognitive functioning in CAN users. (JINS, 2019, 25, 134–145)

Keywords

CannabisMarijuanaVO2 maxNeurocognitionEmerging adulthoodAerobic fitness
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 25 , Issue 2 , February 2019 , pp. 134 - 145
Copyright
Copyright © The International Neuropsychological Society 2018 

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