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Modulation of medial temporal lobe activity in epilepsy patients with hippocampal sclerosis during verbal working memory

Published online by Cambridge University Press:  01 July 2009

PABLO CAMPO ,
FERNANDO MAESTÚ ,
IRENE GARCÍA-MORALES ,
ANTONIO GIL-NAGEL ,
BRYAN STRANGE ,
MANUEL MORALES  and
TOMÁS ORTIZ
PABLO CAMPO*
Affiliation:
Center of Magnetoencephalography Dr. Pérez-Modrego, Complutense University of Madrid, Madrid, Spain
FERNANDO MAESTÚ
Affiliation:
Center of Magnetoencephalography Dr. Pérez-Modrego, Complutense University of Madrid, Madrid, Spain Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Madrid, Spain
IRENE GARCÍA-MORALES
Affiliation:
Epilepsy Unit, Neurology Department, University Hospital of San Carlos, Madrid, Spain Epilepsy Unit, Neurology Department, Hospital Ruber Internacional, Madrid, Spain
ANTONIO GIL-NAGEL
Affiliation:
Epilepsy Unit, Neurology Department, Hospital Ruber Internacional, Madrid, Spain
BRYAN STRANGE
Affiliation:
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, United Kingdom
MANUEL MORALES
Affiliation:
Department of Experimental Psychology, University of Seville, Seville, Spain
TOMÁS ORTIZ
Affiliation:
Center of Magnetoencephalography Dr. Pérez-Modrego, Complutense University of Madrid, Madrid, Spain
*
*Correspondence and reprint requests to: Pablo Campo, Centro de Magnetoencefalografía Dr. Pérez Modrego, Pabellón nº 8 Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain. E-mail: pcampo@arrakis.es
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Abstract

It has been traditionally assumed that medial temporal lobe (MTL) is not required for working memory (WM). However, animal lesion and electrophysiological studies and human neuropsychological and neuroimaging studies have provided increasing evidences of a critical involvement of MTL in WM. Based on previous findings, the central aim of this study was to investigate the contribution of the MTL to verbal WM encoding. Here, we used magnetoencephalography (MEG) to compare the patterns of MTL activation of 9 epilepsy patients suffering from left hippocampal sclerosis with those of 10 healthy matched controls while they performed a verbal WM task. MEG recordings allow detailed tracking of the time course of MTL activation. We observed impaired WM performance associated with changes in the dynamics of MTL activity in epilepsy patients. Specifically, whereas patients showed decreased activity in damaged MTL, activity in the contralateral MTL was enhanced, an effect that became significant in the 600- to 700-ms interval after stimulus presentation. These findings strongly support the crucial contribution of MTL to verbal WM encoding and provide compelling evidence for the proposal that MTL contributes to both episodic memory and WM. Whether this pattern is signaling reorganization or a normal use of a damaged structure is discussed. (JINS, 2009, 15, 536–546.)

Keywords

MagnetoencephalographyHippocampusMemoryMemory disordersEpilepsyEpilepsy surgery
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 4 , July 2009 , pp. 536 - 546
Copyright
Copyright © The International Neuropsychological Society 2009

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