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Molecular neurodevelopment: An in vivo31P-1H MRSI study

Published online by Cambridge University Press:  01 September 2009

GERALD GOLDSTEIN ,
KANAGASABAI PANCHALINGAM ,
RICHARD J. MCCLURE ,
JEFFREY A. STANLEY ,
VINCE D. CALHOUN ,
GODFREY D. PEARLSON  and
JAY W. PETTEGREW
GERALD GOLDSTEIN
Affiliation:
VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania
KANAGASABAI PANCHALINGAM
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
RICHARD J. MCCLURE
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
JEFFREY A. STANLEY
Affiliation:
Departments of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan
VINCE D. CALHOUN
Affiliation:
The Mind Research Network, Albuquerque, New Mexico Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico Department of Psychiatry, Yale University, Hartford, Connecticut
GODFREY D. PEARLSON
Affiliation:
Department of Psychiatry, Yale University, Hartford, Connecticut
JAY W. PETTEGREW*
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Behavioral and Community Health Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania
*
*Correspondence and reprint requests to: Jay W. Pettegrew, M.D., Director, Neurophysics Laboratory, RIDC Park, 260 Kappa Drive, Pittsburgh, Pennsylvania, 15238. E-mail: pettegre+@pitt.edu
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Abstract

Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6–18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders. (JINS, 2009, 15, 671–683.)

Keywords

Magnetic resonance spectroscopyPhospholipid metabolismCognitionPhosphocreatineSynapsesBrainChild developmentAdolescent development
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 5 , September 2009 , pp. 671 - 683
Copyright
Copyright © The International Neuropsychological Society 2009

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