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Neuropsychological Deficits in Young Adults Born Small-for-Gestational Age (SGA) at Term

Published online by Cambridge University Press:  24 February 2014

Heidi Furre Østgård ,
Jon Skranes ,
Marit Martinussen ,
Geir W Jacobsen ,
Ann-Mari Brubakk ,
Torstein Vik ,
Are H. Pripp  and
Gro C.C. Løhaugen
Heidi Furre Østgård*
Affiliation:
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway
Jon Skranes
Affiliation:
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway
Marit Martinussen
Affiliation:
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Obstetrics, St. Olav University Hospital, Trondheim, Norway
Geir W Jacobsen
Affiliation:
Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
Ann-Mari Brubakk
Affiliation:
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Pediatrics, St. Olav University Hospital, Trondheim, Norway
Torstein Vik
Affiliation:
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway
Are H. Pripp
Affiliation:
Department of Biostatistics, Epidemiology and Health Economics, Oslo University Hospital, Norway
Gro C.C. Løhaugen
Affiliation:
Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Pediatrics, Sørlandet Hospital, Arendal, Norway
*
Correspondence and reprint requests to: Heidi F. Østgård, Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, 7489 Trondheim, Norway. E-mail: heidi.f.ostgard@ntnu.no
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Abstract

Reduced IQ, learning difficulties and poor school performance have been reported in small-for-gestational-age (SGA) subjects. However, few studies include a comprehensive neuropsychological assessment. Our aim was to study neuropsychological functioning in young adults born SGA at term. A comprehensive neuropsychological test battery was administered to 58 SGA subjects (birth weight <10th centile) born at term, and 81 term non-SGA controls (birth weight ≥10th centile). The SGA group obtained significantly (p < .01) lower scores on the attention, executive and memory domains compared to non-SGA controls and showed higher risk of obtaining scores below −1.5 SD on the memory domain (odds ratio = 13.3, 95% confidence interval: 1.57, 112.47). At a subtest level, the SGA group obtained lower scores on most neuropsychological tests, with significant differences on 6 of 46 measures: the Trail Making Test 3 (letter sequencing), the Wechsler Memory Scale mental control and the auditory immediate memory scale, the Design Fluency, the Stroop 3 (inhibition) and the Visual Motor Integration (VMI) motor coordination subtest. Young adults born SGA score more poorly on neuropsychological tests compared with non-SGA controls. Differences were modest, with more significant differences in the memory domain. (JINS, 2014, 20, 1–11)

Keywords

Neuropsychological testsFetal growth restriction (FGR)Child developmentLow birth weightFollow-up studyCognitive abilities
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 3 , March 2014 , pp. 313 - 323
Copyright
Copyright © The International Neuropsychological Society 2014 

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References

Bakketeig, L.S., Jacobsen, G., Hoffman, H.J., Lindmark, G., Bergsjo, P., Molne, K., Rodsten, J. (1993). Pre-pregnancy risk factors of small-for-gestational age births among parous women in Scandinavia. Acta Obstetricia Gynecologica Scandinavica, 72(4), 273–279.CrossRefGoogle ScholarPubMed
Barker, D.J. (1995). Intrauterine programming of adult disease. Molecular Medicine Today, 1(9), 418–423.Google Scholar
Beery, K. (1997). Administration, scoring and teaching manual for the Beery-Buktenica Developmental Test of Visual Perception and Motor Coordination. Parsippany, NJ: Modern Curriculum Press.Google Scholar
Cruz-Martinez, R., Figueras, F., Oros, D., Padilla, N., Meler, E., Hernandez-Andrade, E., Gratacos, E. (2009). Cerebral blood perfusion and neurobehavioral performance in full-term small-for-gestational-age fetuses. American Journal of Obstetrics and Gynecology, 201(5), 471–477. doi:10.1016/j.ajog.2009.05.028 Google Scholar
De Jesus, L.C., Pappas, A., Shankaran, S., Li, L., Das, A., Bell, E.F., Higgins, R.D. (2013). Outcomes of small for gestational age infants born at <27 weeks’ gestation. Journal of Pediatrics, 163(1), 55–60. doi:10.1016/j.jpeds.2012.12.097 Google Scholar
Fewtrell, M.S., Kennedy, K., Singhal, A., Martin, R.M., Ness, A., Hadders-Algra, M., Lucas, A. (2008). How much loss to follow-up is acceptable in long-term randomised trials and prospective studies? Archives of Disease in Childhood, 93(6), 458–461. doi:10.1136/adc.2007.127316 CrossRefGoogle ScholarPubMed
Figueras, F., Oros, D., Cruz-Martinez, R., Padilla, N., Hernandez-Andrade, E., Botet, F., Gratacos, E. (2009). Neurobehavior in term, small-for-gestational age infants with normal placental function. Pediatrics, 124(5), 934–941. doi:10.1542/peds.2008-3346 Google Scholar
Foulder-Hughes, L.A., Cooke, R.W. (2003). Motor, cognitive, and behavioural disorders in children born very preterm. Developmental Medicine and Child Neurology, 45(2), 97–103.Google Scholar
Geva, R., Eshel, R., Leitner, Y., Fattal-Valevski, A., Harel, S. (2006). Neuropsychological outcome of children with intrauterine growth restriction: A 9-year prospective study. Pediatrics, 118(1), 91–100. doi:10.1542/peds.2005-2343 CrossRefGoogle ScholarPubMed
Geva, R., Eshel, R., Leitner, Y., Fattal-Valevski, A., Harel, S. (2008). Verbal short-term memory span in children: Long-term modality dependent effects of intrauterine growth restriction. Journal of Child Psychology and Psychiatry, 49(12), 1321–1330. doi:10.1111/j.1469-7610.2008.01917.x Google Scholar
Harrington, D. (2009). Confirmatory factor analysis. New York, NY: Oxford University Press.Google Scholar
Heinonen, K., Pesonen, A.K., Lahti, J., Pyhala, R., Strang-Karlsson, S., Hovi, P., Raikkonen, K. (2013). Self- and parent-rated executive functioning in young adults with very low birth weight. Pediatrics, 131(1), 243–250. doi:10.1542/peds.2012-0839 CrossRefGoogle ScholarPubMed
Heinonen, K., Raikkonen, K., Pesonen, A.K., Andersson, S., Kajantie, E., Eriksson, J.G., Lano, A. (2010). Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term children born small and appropriate for gestational age: A longitudinal study. BMC Pediatrics, 10, 91. doi:10.1186/1471-2431-10-91 Google Scholar
Hollingshead, A.B. (1958). Two factor index of social position. New Haven, CT: Yale University Press.Google Scholar
Kulseng, S., Jennekens-Schinkel, A., Naess, P., Romundstad, P., Indredavik, M., Vik, T., Brubakk, A.M. (2006). Very-low-birthweight and term small-for-gestational-age adolescents: Attention revisited. Acta Paediatrica, 95(2), 224–230. doi:10.1080/08035250500421568 Google Scholar
Leitner, Y., Harel, S., Geva, R., Eshel, R., Yaffo, A., Many, A. (2012). The neurocognitive outcome of IUGR children born to mothers with and without preeclampsia. Journal of Maternal-Fetal and Neonatal Medicine, 25(11), 2206–2208. doi:10.3109/14767058.2012.684164 Google Scholar
Lohaugen, G.C., Ostgard, H.F., Andreassen, S., Jacobsen, G.W., Vik, T., Brubakk, A.M., Martinussen, M. (2013). Small for gestational age and intrauterine growth restriction decreases cognitive function in young adults. Journal of Pediatrics, 163(2), 447–453. doi:10.1016/j.jpeds.2013.01.060 Google Scholar
Lund, L.K., Vik, T., Lydersen, S., Lohaugen, G.C., Skranes, J., Brubakk, A.M., Indredavik, M.S. (2012). Mental health, quality of life and social relations in young adults born with low birth weight. Health and Quality of Life Outcomes, 10, 146. doi:10.1186/1477-7525-10-146 Google Scholar
Lund, L.K., Vik, T., Skranes, J., Brubakk, A.M., Indredavik, M.S. (2011). Psychiatric morbidity in two low birth weight groups assessed by diagnostic interview in young adulthood. Acta Paediatrica, 100(4), 598–604. doi:10.1111/j.1651-2227.2010.02111.x CrossRefGoogle ScholarPubMed
Lundgren, E.M., Cnattingius, S., Jonsson, B., Tuvemo, T. (2001). Intellectual and psychological performance in males born small for gestational age with and without catch-up growth. Pediatric Research, 50(1), 91–96.Google Scholar
Markestad, T., Vik, T., Ahlsten, G., Gebre-Medhin, M., Skjaerven, R., Jacobsen, G., Bakketeig, L.S. (1997). Small-for-gestational-age (SGA) infants born at term: Growth and development during the first year of life. Acta Obstetricia Gynecologia Scandinavia Supplemental, 165, 93–101.Google Scholar
Muthén, L.K., Muthén, B.O. (1998-2012). Mplus user's guide. Los Angeles, CA: Muthén & Muthén.Google Scholar
O'Keeffe, M.J., O'Callaghan, M., Williams, G.M., Najman, J.M., Bor, W. (2003). Learning, cognitive, and attentional problems in adolescents born small for gestational age. Pediatrics, 112(2), 301–307.Google Scholar
Pollack, R.N., Divon, M.Y. (1992). Intrauterine growth retardation: Definition, classification, and etiology. Clinical Obstetrics and Gynecology, 35(1), 99–107.Google Scholar
Pyhälä, R., Lahti, J., Heinonen, K., Pesonen, A.K., Strang-Karlsson, S., Hovi, P., Raikkonen, K. (2011). Neurocognitive abilities in young adults with very low birth weight. Neurology, 77(23), 2052–2060. doi:10.1212/WNL.0b013e31823b473e Google Scholar
Skjaerven, R., Gjessing, H.K., Bakketeig, L.S. (2000). Birthweight by gestational age in Norway. Acta Obstetricia Gynecologia Scandinavia, 79(6), 440–449.Google Scholar
Sommerfelt, K., Andersson, H.W., Sonnander, K., Ahlsten, G., Ellertsen, B., Markestad, T., Bakketeig, L. (2000). Cognitive development of term small for gestational age children at five years of age. Archives of Disease in Childhood, 83(1), 25–30.Google Scholar
Sommerfelt, K., Sonnander, K., Skranes, J., Andersson, H.W., Ahlsten, G., Ellertsen, B., Bakketeig, L.S. (2002). Neuropsychologic and motor function in small-for-gestation preschoolers. Pediatric Neurology, 26(3), 186–191.Google Scholar
Strauss, R.S. (2000). Adult functional outcome of those born small for gestational age: Twenty-six-year follow-up of the 1970 British Birth Cohort. Journal of the American Medical Association, 283(5), 625–632.Google Scholar
Strauss, E., Sherman, E., Spreen, O. (2006). A compendium of neuropsychological tests: Administration, norms and commentary (Vol. 3), New York, NY: Oxford University Press.Google Scholar
Taylor, H.G., Minich, N., Bangert, B., Filipek, P.A., Hack, M. (2004). Long-term neuropsychological outcomes of very low birth weight: Associations with early risks for periventricular brain insults. Journal of the International Neuropsychological Society, 10(7), 987–1004.Google Scholar
Tulsky, D.S., Saklofske, D.H., Heaton, R.K., Bornstein, R., Ledbetter, M., Chelene, G.J., Prifitera, A. (2003). Clinical interpretation of the WAIS-III and WMS-III. San Diego, CA: Academic Press.Google Scholar
Urquia, M.L., Ray, J.G. (2012). Seven caveats on the use of low birthweight and related indicators in health research. Journal of Epidemiology and Community Health, 66(11), 971–975. doi:10.1136/jech-2011-200772.CrossRefGoogle ScholarPubMed
Viggedal, G., Lundalv, E., Carlsson, G., Kjellmer, I. (2004). Neuropsychological follow-up into young adulthood of term infants born small for gestational age. Medical Science Monitor, 10(1), CR8–CR16.Google Scholar
Volpe, J.J. (1995). Neurology of the newborn. Philadelphia, PA: Saunders.Google Scholar
Wollmann, H.A. (1998). Intrauterine growth restriction: Definition and etiology. Hormone Research, 49(Suppl 2), 1–6.Google Scholar
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