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Verbal Fluency in Patients Receiving Bilateral versus Left-Sided Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson's Disease

Published online by Cambridge University Press:  23 January 2012

Rickard L. Sjöberg ,
Elin Lidman ,
Björn Häggström ,
Marwan I. Hariz ,
Jan Linder ,
Anna Fredricks  and
Patric Blomstedt
Rickard L. Sjöberg*
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Elin Lidman
Affiliation:
Karolinska Institute, Department of Neuroscience Stockholm, Sweden
Björn Häggström
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Marwan I. Hariz
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden UCL Institute of Neurology, Queens Square, London, United Kingdom
Jan Linder
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Anna Fredricks
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Patric Blomstedt
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
*
Correspondence and reprint requests to: Rickard L. Sjöberg, Department of Neurosurgery, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden. E-mail: rickard.l.sjoberg@gmail.com
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Abstract

The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation. (JINS, 2012, 18, 606–611)

Keywords

Verbal fluency disordersBasal gangliaPsychological side effectsStereotaxic techniquesFunctional lateralityMovement disorders
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 3 , May 2012 , pp. 606 - 611
Copyright
Copyright © The International Neuropsychological Society 2012

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