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Pre-symptomatic Influenza Transmission, Surveillance, andSchool Closings: Implications for Novel Influenza A (H1N1)

Published online by Cambridge University Press:  28 April 2010

G. F. Webb ,
Y-H. Hsieh ,
J. Wu  and
M. J. Blaser
G. F. Webb*
Affiliation:
Department of Mathematics, Vanderbilt University, Nashville, Tennessee, 37240 USA
Y-H. Hsieh
Affiliation:
Department of Public Health and Center for Infectious Disease Epidemiology Research, China Medical University, Taichung, Taiwan
J. Wu
Affiliation:
Laboratory for Industrial and Applied Mathematics, Centre for Disease Modeling, Department of Mathematics and Statistics, York University, Toronto, Canada M3J 1P3
M. J. Blaser
Affiliation:
Department of Medicine and Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
*
*Corresponding author. E-mailglenn.f.webb@vanderbilt.edu
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Abstract

Early studies of the novel swine-origin 2009 influenza A (H1N1) epidemic indicateclinical attack rates in children much higher than in adults. Non-medical interventionssuch as school closings are constrained by their large socio-economic costs. Here wedevelop a mathematical model to ascertain the roles of pre-symptomatic influenzatransmission as well as symptoms surveillance of children to assess the utility of schoolclosures. Our model analysis indicates that school closings are advisable whenpre-symptomatic transmission is significant or when removal of symptomatic children isinefficient. Our objective is to provide a rational basis for school closings decisionsdependent on virulence characteristics and local surveillance implementation, applicableto the current epidemic and future epidemics.

Keywords

influenzasymptoms surveillancepre-symptomaticage of infection modelschool closing policy
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 5 , Issue 3: Mathematical modeling in the medical sciences , 2010 , pp. 191 - 205
Copyright
© EDP Sciences, 2010

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