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Cells spreading on Micro-fabricated Silica Thin film Coatings

Published online by Cambridge University Press:  21 August 2009

A. Pelaez-Vargas ,
N. Ferrell ,
M. H. Fernandes ,
D. Hansford  and
F. J. Monteiro
A. Pelaez-Vargas
Affiliation:
INEB - Instituto de Engenharia Biomédica, Divisão de Biomateriais, Universidade do Porto, Portugal and Departamento de Engenharia Metalúrgica e Materiais, FEUP - Faculdade de Engenharia, Universidade do Porto, Portugal
N. Ferrell
Affiliation:
Department of Biomedical Engineering, Ohio State University, Columbus (Ohio)USA
M. H. Fernandes
Affiliation:
Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentária, Universidade do Porto, Portugal
D. Hansford
Affiliation:
Department of Biomedical Engineering, Ohio State University, Columbus (Ohio)USA
F. J. Monteiro
Affiliation:
INEB - Instituto de Engenharia Biomédica, Divisão de Biomateriais, Universidade do Porto, Portugal and Departamento de Engenharia Metalúrgica e Materiais, FEUP - Faculdade de Engenharia, Universidade do Porto, Portugal

Abstract

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From a biomaterials perspective, it is now understood that success in the osseointegration of a dental implant is conditioned by its “macro”, “micro” and “nano” scale features. Macro-scale roughness is necessary to improve primary stabilization in the post-surgical phase inducing a peri-implant thin fibrous layer. However, the more complex process in the true cell-material interaction is dependent on micro and nano scale phenomena. There is clear evidence that cell adhesion, proliferation, organization and phenotype are modulated at the micro-scale and that protein absorption is fundamentally a process conditioned at nano-scale.

Type
Materials Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 77 - 78
Copyright
Copyright © Microscopy Society of America 2009