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Gender and aging in the liver: preliminary data using design-based stereological methods

Published online by Cambridge University Press:  21 August 2009

Ricardo Marcos ,
Fernanda Malhão ,
Rogério Monteiro  and
Eduardo Rocha
Ricardo Marcos
Affiliation:
Laboratory of Histology and Embryology, ICBAS — Institute of Biomedical Sciences Abel Salazar, University of Porto, Largo Prof Abel Salazar nº 2, 4099-003 Porto, Portugal
Fernanda Malhão
Affiliation:
Laboratory of Histology and Embryology, ICBAS — Institute of Biomedical Sciences Abel Salazar, University of Porto, Largo Prof Abel Salazar nº 2, 4099-003 Porto, Portugal
Rogério Monteiro
Affiliation:
Laboratory of Histology and Embryology, ICBAS — Institute of Biomedical Sciences Abel Salazar, University of Porto, Largo Prof Abel Salazar nº 2, 4099-003 Porto, Portugal Laboratory of Cellular, Molecular and Analytical Studies, CIIMAR — Interdisciplinary Centre for Marine and Environmental Research, CIMAR Associated Laboratory, University of Porto, Rua dos Bragas nº 289, 4050-123 Porto, Portugal
Eduardo Rocha
Affiliation:
Laboratory of Histology and Embryology, ICBAS — Institute of Biomedical Sciences Abel Salazar, University of Porto, Largo Prof Abel Salazar nº 2, 4099-003 Porto, Portugal Laboratory of Cellular, Molecular and Analytical Studies, CIIMAR — Interdisciplinary Centre for Marine and Environmental Research, CIMAR Associated Laboratory, University of Porto, Rua dos Bragas nº 289, 4050-123 Porto, Portugal

Abstract

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Different epidemiological studies demonstrated that male gender and age are risk factors for the progression of liver disease. Regarding age, it has been associated with liver mass and blood flow reduction, whereas in gender, the estradiol has revealed protective roles in models of liver fibrosis and of trauma-hemorrhage in rats. So far, most of the studies on aging focused their attention in hepatocyte (HEP) structure and function and few data exists pertaining to other liver cell subpopulations, including hepatic stellate cells (HSC) and Kupffer cells (KC). To the best of our knowledge, an integrative analysis (with modern stereology) of the liver cell populations, throughout aging and gender, has never been performed.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 45 - 46
Copyright
Copyright © Microscopy Society of America 2009