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Immune System Activation After Cisplatin or “Poly-Plat” Treatment: An in Vivo Study

Published online by Cambridge University Press:  02 July 2020

D. J. Telgen  and
S. K. Aggarwal
D. J. Telgen
Affiliation:
Department of Zoology, Michigan State University, East Lansing, MI48824-1115
S. K. Aggarwal
Affiliation:
Department of Zoology, Michigan State University, East Lansing, MI48824-1115
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Extract

Cisplatin (cw-diamminedichloroplatinum II; CDDP) is a broad spectrum anti-cancer agent with severe toxic side effects. New platinum based chemotherapeutic agents with similar properties are in constant development. Poly-plat (Poly-[(teans-l,2-diaminocyclohexane) platinum]-carboxyamylose), a novel second generation platinum chemotherapeutic agent, has been shown to be less toxic compared to CDDP. The purpose of this paper was to examine the morphological changes in the Kupffer cells in the liver after poly-plat treatment in rats and compare the results obtained after CDDP. Peripheral blood was also examined for levels of circulating leukocytes.

Wistar rats (120-160 g) were given intraperitoneal injections of either CDDP (9 mg/kg in 0.9% sodium chloride) or poly-plat (10 mg/kg in 0.9% sodium chloride) over a five day period. Controls were treated with equal amounts of the vehicle of injection. Peripheral blood was collected via tail vein beginning 1 day prior to treatment and continuing 10 days after treatment.

Type
Application of Classical and Novel Microscopy to Tissue Injury and Infectious Disease Pathogenesis
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1048 - 1049
Copyright
Copyright © Microscopy Society of America

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