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Immunofluorescent study of the expression of Ang1, Ang2 and Tie2 in the corpus cavernosum of the Rat during aging

Published online by Cambridge University Press:  21 August 2009

António Figueiredo ,
Ana Lúcia Cordeiro ,
Henrique Almeida  and
Delminda Neves
António Figueiredo
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto4200-319 Porto, Portugal
Ana Lúcia Cordeiro
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto4200-319 Porto, Portugal
Henrique Almeida
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto4200-319 Porto, Portugal
Delminda Neves
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto4200-319 Porto, Portugal

Abstract

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Aging is a recognized risk factor for erectile dysfunction (ED) contributing to vascular damage of penile tissue. Vascular system seems to be particularly prone to develop dysfunction along chronological aging, as supported by studies that associate aging with reduced endothelium-dependent dilation, atherosclerosis progression and angiogenic deficit in specific tissues. Cavernous tissue is particularly sensitive to atherosclerotic disease and to structural changes of the small vessels of the penis which conduces to functional impairment.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 13 - 14
Copyright
Copyright © Microscopy Society of America 2009