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Molecular pathology - Implications for Diagnosis and Pathogenesis of Infectious Diseases.

Published online by Cambridge University Press:  02 July 2020

S.R. Zaki
S.R. Zaki*
Affiliation:
Infectious Disease Pathology Activity, Division of Viral & Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control & Prevention, Atlanta, GA30333
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Extract

Molecular pathology represents a distinctive new discipline in medicine with many potential applications that have been heretofore untapped. This discipline is introducing important changes in the concepts of disease causation and in the classification of diseases. Transfer of molecular genetic technology and knowledge to the pathology laboratory is giving the pathologist new and powerful tools to diagnose, classify, and monitor disease. Methodologies such as in situ hybridization (ISH), immunohistochemistry (IHC), and the polymerase chain reaction (PCR) will continue to allow more systematic and accurate classification of human diseases. IHC and ISH allow the identification and localization of cells containing specific antigens or nucleic acid sequences. The main advantage of these methods is their ability to localize targets and define their morphologic features in various tissues, allowing correlations with histopathologic changes.

Type
Application of Classical and Novel Microscopy to Tissue Injury and Infectious Disease Pathogenesis
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1046 - 1047
Copyright
Copyright © Microscopy Society of America

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References

1.Zaki, S. R. et al., Hantavirus pulmonary syndrome: Pathogenesis of an emerging infectious disease. American Journal of Pathology, 1995;146:552–579.Google ScholarPubMed
2.Zaki, S. R. and Peters, C. J.. Viral hemorrhagic fevers. In: Pathology of Infectious Diseases. Eds. Connor, DH, Chandler, FW, Schwartz, DA, Manz, HJ, Lack, E.E.; Appleton and Lange, Stamford, CT, 1997; 347–364.Google Scholar
3.Zaki, S. R. et al., Leptospirosis associated with an outbreak of acute febrile illness and pulmonary hemorrhage, Nicaragua 1995. Lancet, 1996; 347:535–536.Google Scholar