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Morphometric and molecular study of corpus cavernosum of the rat after longterm high-fat diet intake

Published online by Cambridge University Press:  21 August 2009

I. Tomada ,
N. Tomada ,
H. Almeida ,
P. Vendeira  and
D. Neves
I. Tomada
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto, Alameda Professor Hernãni Monteiro, 4200-319 Porto, Portugal
N. Tomada
Affiliation:
Department of Urology ofS. João Central Hospital, Alameda Professor Hernãni Monteiro, 4200- 319 Porto, Portugal
H. Almeida
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto, Alameda Professor Hernãni Monteiro, 4200-319 Porto, Portugal
P. Vendeira
Affiliation:
Department of Urology ofS. João Central Hospital, Alameda Professor Hernãni Monteiro, 4200- 319 Porto, Portugal
D. Neves
Affiliation:
Laboratory of Molecular Cell Biology of Faculty of Medicine and IBMC of Universidade do Porto, Alameda Professor Hernãni Monteiro, 4200-319 Porto, Portugal

Abstract

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Erectile dysfunction (ED) is considered equivalent to endothelial dysfunction and thus an early manifestation of atherosclerosis and cardiovascular disease (CVD). Atherosclerosis that is frequently provoked by regular consumption of high-fat diet (HFD) has been recently recognized as a chronic inflammation condition associated to vessel lipid deposition and vascular smooth cells proliferation that together impair endothelium-dependent relaxation of corpus cavernosum (CC) smooth muscle. It is also well established that HFD regular intake by its own induces endothelial dysfunction. The main objective of this study was to evaluate effects of HFD continuous intake on atherosclerosis progression of CC vessels of the rat. Due to their intervention on atherosclerosisrelated vascular remodelling pathways, angiopoietins (Ang1, Ang2) expression in erectile tissue of this rat experimental model was characterized.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 21 - 22
Copyright
Copyright © Microscopy Society of America 2009