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Onset of Appearance and Potential Significance of Telocytes in the Developing Fetal Lung

Published online by Cambridge University Press:  16 September 2019

Mahmoud Awad ,
Wafaa Gaber  and
Dalia Ibrahim
Mahmoud Awad
Affiliation:
Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
Wafaa Gaber
Affiliation:
Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Assuit University, Assuit, Egypt
Dalia Ibrahim*
Affiliation:
Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
*
*Author for correspondence: D. Ibrahim, E-mail: dalia.mohamadain@vet.svu.edu.eg; daliamahmoud.histology@gmail.com
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Abstract

CD34, vimentin, and vascular endothelial growth factor immunohistochemical analysis and electron microscopic tools were employed to record the initial appearance of telocytes (TCs) and stage-by-stage variations in TC localizations in the developing rabbit lung. TCs could not be identified in the primitive embryonic lung until day 18 of gestation. In the pseudoglandular lung, CD34+ TCs had been recorded under the cartilage of the main bronchus, in the wall of large-sized pulmonary vessels and large epithelial tubes. In the canalicular phase, TCs could be demonstrated in the smooth muscle layer of the bronchioles including the terminal ones. The strength of CD34 immunoreactive signals had been amplified by age until the day of parturition. Ultrastructurally, TCs consisted of a tiny body and exceptionally long telopodes (Tps). The Tp consisted of alternating thin segments (podomers) and dilated ones (podoms). The Tp sometimes branched with a dichotomous pattern. TCs interconnected in a network either by homocellular junctions with neighboring TCs or by heterocellular junctions with smooth muscle cells and alveolar cells. Collectively, early detection of TCs in pulmonary vessels suggests a potential role for TCs in their angiogenesis. For the lung tissue, TCs seem to be involved in the regulation of lung histogenesis.

Keywords

CD34lung developmenttelocyteTEM
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 25 , Issue 5 , October 2019 , pp. 1246 - 1256
Copyright
Copyright © Microscopy Society of America 2019 

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