The M&M 2005 meeting will begin on Saturday, July 30, with a pre-meeting congress entitled “Biophotonics and Live Cell Imaging.” The pre-meeting congress will continue on Sunday along with a number of topical Short Courses addressing digital imaging, image analysis and specimen preparation. Examples of biological topics that will be addressed during the week of the meeting include Tracking and Tagging of Stem Cells, Use of Green and Other Fluorescent Proteins, Cell Communication and Pathology, and the use of microscopy in the study of Viruses, Infectious Diseases and Their Associated Pathologies. Topical symposia in the physical sciences will examine the role of microscopy and microanalysis in the study of Extraterrestrial Materials, Catalysts, and Metallographic Techniques, Applications and Failure Analysis. In joint sessions for biological and materials scientists, several symposia will address the development and imaging of a variety of Nanoparticles, Biopolymers and Biomembranes. Instrumentation and Techniques Development sessions will also address a number of state-of the-art instruments and techniques including Aberration Corrected Electron Microscopy, ESEM, FIB, Advanced Detectors, Spectral Imaging Techniques, FRET, and Tomography. Of special interest will be the Presidential Symposium, “The Golden Anniversary of Imaging Atoms” commemorating the 50th anniversary of the first atomic images using field-ion microscopy, which will provide keynote addresses concerning the historical and advanced technology that has grown from the first application of atomic imaging. This year we will also have a series of topical sessions organized by the Focused Interest Groups of MSA. Supplementing the topical sessions will be a number of Tutorials and Ask the-Experts sessions that will provide the opportunity to learn the basics behind many popular techniques. As always, the commercial exhibits will provide the unique opportunity for hands-on learning with the largest variety of state-of-the-art instrumentation found at any microscopy meeting worldwide. The poster sessions will again provide the best venue for discussions and exchange of scientific information. To facilitate communication, we have made arrangements to have appropriate kegs of beverages available on the exhibit floor during the 3:30–5:00 PM afternoon poster sessions. To promote this interaction, posters should be put up Monday morning and not removed until after the Wednesday afternoon Poster Session ends. It is the sincere hope of the Executive Program Committee that the Scientific Program will be of interest to all microscopists in the Pacific Rim countries. We look forward to meeting and interacting with as many of you as possible in Hawaii.