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Tramadol Biological Effects: 4: Effective Therapeutic Efficacy of Lagenaria siceraria Preparation (Gamal & Aref1) and Melatonin on Cell Biological, Histochemical, and Histopathological Changes in the Kidney of Tramadol-Induced Male Mice

Part of: Micrographia Collection

Published online by Cambridge University Press:  08 April 2021

Abdel-Baset M. Aref ,
Maha A. Momenah ,
Mariam M. Jad ,
Margit Semmler ,
Hoda S. Mohamedaiin ,
Ahmed Ahmed  and
Dalia Mohamedien Open the ORCID record for Dalia Mohamedien [Opens in a new window]
Abdel-Baset M. Aref*
Affiliation:
Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt
Maha A. Momenah
Affiliation:
Zoology Department, Faculty of Science, Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
Mariam M. Jad
Affiliation:
Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt
Margit Semmler
Affiliation:
Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt Diabetes Research Institute, Düsseldorf University, Düsseldorf, Germany
Hoda S. Mohamedaiin
Affiliation:
Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt Zoology Department, Faculty of Science, South Valley University, Qena, Egypt
Ahmed Ahmed
Affiliation:
Urology Department, Faculty of Medicine, Aswan University, Aswan, Egypt
Dalia Mohamedien
Affiliation:
Histology Department, Faculty of Veterinary, South Valley University, Qena, Egypt
*
*Author for correspondence: Abdel-Baset M. Aref, E-mail: aref322189@yahoo.com; abdelbasset.aref@sci.svu.edu.eg
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Abstract

Tramadol is used worldwide and is listed in many medical guidelines to treat both acute and chronic pains. There is a growing evidence of abuse of tramadol in some African and West Asian countries. Tramadol has some side effects. The present study designed to follow up the treatment of the cellular responses which might be induced in the kidney of tramadol mice. Treated mice received daily injection of tramadol dose (125 μg/100 g b.wt) for 20 and 40 days. Other mice received tramadol for 40 days and then were divided into three groups: the first received distilled water, the second received Lagenaria siceraria, and the third received melatonin daily for 40 days. Both the daily injection of tramadol for 20 and 40 days resulted in radical, extensive, and severe alterations in the normal histological architecture of the kidney. Treatment with Lagenaria siceraria or melatonin after tramadol administration for a long-term, markedly changed the collagen content and other chemical components, that may reach nearly normal levels. Such findings propose that although tramadol has many cytological and histopathological side effects on the kidneys of male mice, the treatments via Lagenaria siceraria and melatonin have effective therapeutic impacts on the tramadol side effects.

Keywords

cell biologyhistochemistryhistopathologykidneyLagenaria sicerariamale micemelatonintramadol
Type
Micrographia
Information
Microscopy and Microanalysis , Volume 27 , Issue 3 , June 2021 , pp. 613 - 625
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

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