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Ultrastructure of the Effects of Pyrrolidine-fused Chlorins on the Replication of HSV-1

Published online by Cambridge University Press:  03 October 2008

António P.A. Matos ,
Ana R.N. Santos ,
Maria F. Caeiro ,
Maria A.F. Faustino ,
M.G.P.M.S. Neves ,
A.C. Tomé  and
José A.S. Cavaleiro
António P.A. Matos
Affiliation:
Dental Medical School, University of Lisbon 1649-003 Lisbon and Curry Cabral Hospital, 1069-166 Lisbon, Portugal
Ana R.N. Santos
Affiliation:
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Maria F. Caeiro
Affiliation:
University of Lisbon, Faculty of Sciences, Department of Plant Biology and Environmental Biology Centre, 179-016 LisbonPortugal
Maria A.F. Faustino
Affiliation:
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
M.G.P.M.S. Neves
Affiliation:
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
A.C. Tomé
Affiliation:
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
José A.S. Cavaleiro
Affiliation:
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

Abstract

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Currently, only few antiviral drugs of proven effectiveness exist against virus of the Herpesviridae family and viral resistance to these drugs, especially in the immunocompromised hosts, has encouraged research for new drugs. Some porphyrin derivatives revealed a significant antiviral activity against HSV-1 virus. However the cellular target of the porphyrin derivatives in the virus-cell complex remains unknown.

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Abstract
Information
Microscopy and Microanalysis , Volume 14 , Supplement S3 , September 2008 , pp. 137 - 138
Copyright
Copyright © Microscopy Society of America 2008