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Cryoelectron Tomography

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael
Stephen W. Carmichael*
Affiliation:
Mayo Clinic
*
carmichael.stephen@mayo.edu

Extract

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We have all seen beautiful three-dimensional (3D) renderings of molecular models, complete with helices and pleated sheets. And for more than half a century we have also seen electron micrographs of cellular structures, although usually in two dimensions. There has been a gap between these two sets of images. By developing a technique that promises 3D images at resolutions approaching the molecular level, Ohad Medalia, Igor Weber, Achilleas Frangakis, Daniela Nicastro Günther Gerisch, and Wolfgang Baumeister have bridged that gap.

Type
Research Article
Information
Microscopy Today , Volume 11 , Issue 3 , June 2003 , pp. 3 - 4
Copyright
Copyright © Microscopy Society of America 2003

Footnotes

1

The author gratefully acknowledges Dr. Wolfgang Baumeister for reviewing this article.

References

2Medalia, O., J. Weber, A.S. Frangakts, Dr Nicastro, G. Gerisch, and W. Baumeister, Macromolecular architecture In eukaryotic cells visualized by cryoelectron tomography, Science 298:1209-1213, 2002.CrossRefGoogle Scholar
3Koster A.J., R. Grimm, D. Typke, R. Hegerl, A. Stoschek, J. Walz and W. Baumeister, Perspectives of molecular and cellular electron tomography, J. Struct, Biol.120:276-308, 1997.CrossRefGoogle Scholar