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Looking at Proteins Interacting and Folding inside Cells

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael
Stephen W. Carmichael*
Affiliation:
Mayo Clinic
*
carmichael.stephen@mayo.edu

Extract

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Fluorescence microscopy has revolutionized cell biology. Not only has it increased the spatial resolution with which certain processes are visualized, but it has allowed microscopists to monitor more than one event at a time. One of the remaining challenges is to see how proteins fold and assume their native conformations within living cells. Recently, Nathan Luedtke, Rachel Dexter, Daniel Fried, and Alanna Schepartz have demonstrated a technique to demonstrate these events in situ.

Type
Research Article
Information
Microscopy Today , Volume 16 , Issue 3 , May 2008 , pp. 3 - 5
Copyright
Copyright © Microscopy Society of America 2008

Footnotes

1

The author gratefully acknowledges Dr. Alanna Schepartz for reviewing this article.

References

Note

2 Luedtke, N.W., Dexter, R.J., Fried, D.B., and Schepartz, A., Surveying polypeptide and protein domain configuration and association with FlAsH and ReAsH, Nature Chem. Biol. 3:779-784, 2007.CrossRefGoogle Scholar