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Optical Projection Tomography

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael  and
Stephen A. Boppart
Stephen W. Carmichael*
Affiliation:
Mayo Clinic
Stephen A. Boppart*
Affiliation:
University of Illinois at Urbana-Champaign
*
carmichael.stephen@mayo.edu
boppart@uiuc.edu

Extract

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There are many approaches to obtaining high-resolution images and three dimensional volumetric data sets, but all have limitations. Many techniques involve reconstructing volumes of information from sections, either physical sections or optical sections. Recently, James Sharpe, Ulf Ahlgren, Paul Perry, Bill Hill, Allyson Ross, Jacob Hecksher-Sørensen, Richard Baldock, and Duncan Davidson have developed an optical technique that is analogous to computed tomography (CT). Whereas clinical CT involves an X-ray source and detector rotating around the patient, optical projection tomography (OPT) has the specimen rotating within an optical pathway.

Type
Research Article
Information
Microscopy Today , Volume 10 , Issue 5 , September 2002 , pp. 3 - 4
Copyright
Copyright © Microscopy Society of America 2002

Footnotes

1

The authors gratefully acknowledge Dr. James Sharpe for reviewing this article.

References

References:

2 Sharpe, J., Ahlgren, U., Perry, P., Hill, B., Ross, A., Heoksher-Sørensen, J., Baldock, R., and Davidson, D., Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies, Science 296:541–545, 2002.CrossRefGoogle ScholarPubMed