Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-28T15:27:13.824Z Has data issue: false hasContentIssue false
  • English
  • Français

Plugging A Small Hole

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael
Stephen W. Carmichael*
Affiliation:
Mayo Clinic

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

It has long been appreciated that communication between the nucleus and the cytoplasm of a cell occurs through the nuclear pores. Regulation of this communication has remained a mystery. A breakthrough in our understanding of this regulation was recently presented by Carmen Perez- Terzic, Jason Pyle, Marisa Jaconi, Lisa Stehnc-Bittel, and David Clapham of Mayo Clinic. Using field emission scanning electron microscopy (FESEM), transmission electron microscopy, and atomic force microscopy (AFM), they demonstrated the presence of a small plug within the nuclear pore that was present under certain physiologic circumstances. This “plug“ may regulate the movement of molecules through the pore.

Type
Research Article
Information
Microscopy Today , Volume 5 , Issue 1 , January 1997 , pp. 3 - 4
Copyright
Copyright © Microscopy Society of America 1997

References

Note

1 Perez-Terzic, C,Pyie, J., Stehno-Bittel, L.,Clapham, D.E, Conformationaf states of the nuclear pore complex induced by depletion of nuclear CA2+ stores Science 273:1875-1877, 1996.Google ScholarPubMed