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Watching Neurons Hand Off Molecules

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael
Stephen W. Carmichael*
Affiliation:
Mayo Clinic
*
carmichael.stephen@mayo.edu

Extract

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Since the discovery of nerve growth factor, it has been thought that neurotrophic factors are released or secreted from target cells. However, more recently it has been suggested that a specific neurotrophic factor known as brain-derived neurotrophic factor (BDNF) may reach target cells directly from pre-synaptic axons. It has not been known how these molecules get from the neuron in which they are produced to the target cells. Keigo Kohara, Akihiko Kitamura, Mieko Morishima, and Tadaharu Tsumoto have demonstrated that BDNF is transported anterogradely from presynaptic neurons to target neurons.

Type
Research Article
Information
Microscopy Today , Volume 10 , Issue 1 , February 2002 , pp. 3 - 34
Copyright
Copyright © Microscopy Society of America 2002

Footnotes

1

The author gratefully acknowledges Professor Tadaharu Tsumoto for reviewing this article

References

Note

2. Kohara, K., Kitamura, A., Morishima, M., Tsumoto, T., Activity-dependent transfer of brain-derived neurotrophic factor to postsynaptic neurons, Science 291:2419–2423, 2001.CrossRefGoogle ScholarPubMed