Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-10T07:50:19.098Z Has data issue: false hasContentIssue false
  • English
  • Français

3D Printed PLA/PCL/TiO2 Composite for Bone Replacement and Grafting

Published online by Cambridge University Press:  23 April 2018

Sandra E. Nájera ,
Monica Michel  and
Nam-Soo Kim
Sandra E. Nájera
Affiliation:
Metallurgical, Materials and Biomedical Engineering Department, The University of Texas at El Paso, El Paso, TX, USA Printing Nano Engineering Lab, Metallurgical, Materials and Biomedical Engineering Department, The University of Texas at El Paso, El Paso, TX, USA
Monica Michel
Affiliation:
Metallurgical, Materials and Biomedical Engineering Department, The University of Texas at El Paso, El Paso, TX, USA Printing Nano Engineering Lab, Metallurgical, Materials and Biomedical Engineering Department, The University of Texas at El Paso, El Paso, TX, USA
Nam-Soo Kim*
Affiliation:
Metallurgical, Materials and Biomedical Engineering Department, The University of Texas at El Paso, El Paso, TX, USA Printing Nano Engineering Lab, Metallurgical, Materials and Biomedical Engineering Department, The University of Texas at El Paso, El Paso, TX, USA
*
*(Email: nkim@utep.edu)
Get access

Abstract

Polymer composites of Polylactic acid (PLA) and poly-ε-caprolactone (PCL), containing small amounts of titanium oxide (TiO2) were developed for biomedical applications. These composite materials were prepared, and then printed using Fused Deposition Modeling (FDM). 3D printed structures were characterized to determine their mechanical properties and biocompatibility. DSC analysis yielded useful information regarding the immiscibility of the different polymers, and it was observed that the particles of TiO2 improved the stability of the polymers. The ultimate tensile strength and the fracture strain increased by adding TiO2 as a filler, resulting in values of approximately 45 MPa and 5.5 % elongation. The printed composites show excellent in vitro biocompatibility including cell proliferation and adhesion, and are therefore promising candidates to be used in the biomedical field for bone replacement procedures, due to their properties similar to those of cancellous bone.

Keywords

3D printingbiomaterialbonepolymercomposite
Type
Articles
Information
MRS Advances , Volume 3 , Issue 40: Soft Materials and Biomaterials , 2018 , pp. 2373 - 2378
Copyright
Copyright © Materials Research Society 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brydone, AS., Meek, D., and Maclaine, S., Proc. Inst. Mech. Eng. H., 224(12), 1329–1343 (2010).CrossRefGoogle Scholar
Choi, K., Kuhn, J. L., Ciarelli, M. J., and Goldstein, S. A., J. Biomech., 23(11), 1103–1113 (1990).CrossRefGoogle Scholar
Tan, L., Yu, X., Wan, P., and Yang, K., J. Mater. Sci. Technol., 29(6), 503–513 (2013).CrossRefGoogle Scholar
Ren, Z., Li, H., Sun, X., Yan, S., and Yang, Y., Ind. Eng. Chem. Res., 51(21), 7273–7278 (2012).CrossRefGoogle Scholar
Santosh, M. et al. , Acta Biomater., 6(7), 2467–2476 (2011).Google Scholar
Zhang, J. et al. , Toxi. Ind. Health, 29(6), 523–533 (2012).CrossRefGoogle Scholar
Hamzeh, M. and Sunahara, G. I., Toxi. in Vitro, 27(2), 864–873 (2013).CrossRefGoogle Scholar
Visai, L. et al. , Int. J. Artif. Organs, 34(9), 929–946 (2011).CrossRefGoogle Scholar
Saeidlou, S., Huneault, M. A., Li, H., and Park, C. B., Prog. Polym. Sci., 37(12), 1657–1677 (2012).CrossRefGoogle Scholar