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Biodegradable nano-architectures containing gold nanoparticles arrays

Published online by Cambridge University Press:  16 June 2016

Domenico Cassano ,
Diego Rota Martir ,
Giovanni Signore ,
Cinzia Avigo ,
Luca Menichetti ,
Vincenzo Piazza  and
Valerio Voliani
Domenico Cassano
Affiliation:
NEST-Scuola Normale Superiore, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy
Diego Rota Martir
Affiliation:
Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy
Giovanni Signore
Affiliation:
Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy
Cinzia Avigo
Affiliation:
Istituto di fisiologia clinica, CNR-IFC, Pisa (PI), Italy
Luca Menichetti
Affiliation:
Istituto di fisiologia clinica, CNR-IFC, Pisa (PI), Italy
Vincenzo Piazza
Affiliation:
Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy
Valerio Voliani*
Affiliation:
Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, 12 - 56126, Pisa (PI), Italy
*
*Corresponding Author: Valerio Voliani (valerio.voliani@iit.it)
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Abstract

One of the major concerns regarding the clinical translation of metal nanoparticles is related to the question of their persistence in organisms that can increase the likelihood of toxicity and the interaction/interference with common medical diagnoses.

In order to overcome these issues we have recently introduced a versatile 90 nm nano-architecture composed by: i) arrays of 3 nm gold nanoparticles, ii) functionalizable commercial polymers surrounding the gold nanoparticles, and iii) biodegradable and derivatizable silica shell embedding the polymer-nanoparticle assembly. These robust nanocapsules maintain the intriguing features of gold nanospheres but are biodegraded in physiological media to their potentially renal clearable building blocks.

Keywords

nanostructurebiomaterialcore/shell
Type
Articles
Information
MRS Advances , Volume 1 , Issue 30: Nanotechnology , 2016 , pp. 2173 - 2179
Copyright
Copyright © Materials Research Society 2016 

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References

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