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Functionalized Polythiophene Copolymers for Electronic Biomedical Devices

Published online by Cambridge University Press:  09 January 2020

Samadhan Nagane ,
Peter Sitarik ,
Yuhang Wu ,
Quintin Baugh ,
Shrirang Chhatre ,
Junghyun Lee  and
David C. Martin Open the ORCID record for David C. Martin [Opens in a new window]
Samadhan Nagane
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
Peter Sitarik
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
Yuhang Wu
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
Quintin Baugh
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
Shrirang Chhatre
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
Junghyun Lee
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
David C. Martin*
Affiliation:
Department of Materials Science and Engineering, The University of Delaware, Newark, DE 19716
*
*(Email: milty@udel.edu)
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Abstract

We continue to investigate the design, synthesis, and characterization of electrically and ionically active conjugated polythiophene copolymers for integrating a variety of biomedical devices with living tissue. This paper will describe some of our most recent results, including the development of several new monomers that can tailor the surface chemistry, adhesion, and biointegration of these materials with neural cells. Our efforts have focused on copolymers of 3,4 ethylenedioxythiophene (EDOT), functionalized variants of EDOT (including EDOT-acid and the trifunctional EPh), and dopamine (DOPA). The resulting PEDOT-based copolymers have electrical, optical, mechanical, and adhesive properties that can be precisely tailored by fine tuning the chemical composition and structure. Here we present results on EDOT-dopamine bifunctional monomers and their corresponding polymers. We discuss the design and synthesis of an EDOT-cholesterol that combines the thiophene with a biological moiety known to exhibit surface-active behaviour. We will also introduce EDOT-aldehyde and EDOT-maleimide monomers and show how they can be used as the starting point for a wide variety of functionalized monomers and polymers.

Keywords

electrodepositionelectrochemical synthesisbiomaterialbiomedicalpolymer
Type
Articles
Information
MRS Advances , Volume 5 , Issue 18-19: Soft Materials and Biomaterials , 2020 , pp. 943 - 956
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Copyright
Copyright © Materials Research Society 2020

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References

References:

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