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Construction of Molecular Shuttles Based on Kinesin Motor Proteins and Microtubules

Published online by Cambridge University Press:  14 March 2011

Daniel Oliveira ,
Kim Domyoung ,
Mitsuo Umetsu ,
Tadafumi Adschiri  and
Winfried Teizer
Daniel Oliveira
Affiliation:
World Premier International - Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
Kim Domyoung
Affiliation:
Dept. of Biomolecular Engineering, Tohoku University, 6-6-11 Aramaki, Aoba-ku, Sendai 980-8579, Japan
Mitsuo Umetsu
Affiliation:
World Premier International - Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan Dept. of Biomolecular Engineering, Tohoku University, 6-6-11 Aramaki, Aoba-ku, Sendai 980-8579, Japan
Tadafumi Adschiri
Affiliation:
World Premier International - Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
Winfried Teizer
Affiliation:
World Premier International - Advanced Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan Dept. of Physics and Astronomy, Texas A&M University, College Station, TX 77843-4242, USA
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Abstract

The intracellular cargo delivery performed by kinesin motor proteins can be biomimetically employed to engineer tailor-made artificial nanotransport systems. Kinesin (expressed on an Escherichia coli system) and microtubules (obtained from the polymerization of tubulin proteins) were prepared and characterized. We report recent results and explore the aim of the construction of biomotor-based NanoElectroMechanical Systems (NEMS) and their potential applications, e.g. as drug delivery systems.

Keywords

biomimetic (assembly)nanostructurebiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1316: Symposium QQ – Nanofunctional Materials, Nanostructures and Nanodevices for Biomedical Applications II , 2011 , mrsf10-1316-qq06-12
Copyright
Copyright © Materials Research Society 2011

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References

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