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Synthesis of Fe3O4/ZnO Core-shell Nanoparticles for Photodynamic Therapy Applications

Published online by Cambridge University Press:  01 February 2011

Juan C. Beltran Huarac ,
Surinder P. Singh ,
Maharaj S. Tomar ,
Sandra Peňa ,
Luis Rivera  and
Oscar Perales-Perez
Juan C. Beltran Huarac
Affiliation:
juan.beltran1@upr.edu, University of Puerto Rico, Mayaguez, Physics, Mayaguez, Puerto Rico
Surinder P. Singh
Affiliation:
surinder.singh@uprm.edu, University of Puerto Rico, Mayaguez, Engineering Science & Materials, Mayaguez, Puerto Rico
Maharaj S. Tomar
Affiliation:
maharaj.tomar@upr.edu, University of Puerto Rico, Mayaguez, Physics, Mayaguez, Puerto Rico
Sandra Peňa
Affiliation:
sandraluengas@yahoo.es, University of Puerto Rico, Mayaguez, Chemistry, Mayaguez, Puerto Rico
Luis Rivera
Affiliation:
luis.upr@gmail.com, University of Puerto Rico, Mayaguez, Chemistry, Mayaguez, Puerto Rico
Oscar Perales-Perez
Affiliation:
operalesperez@yahoo.com, University of Puerto Rico, Mayaguez, Engineering Science & Materials, Mayaguez, Puerto Rico
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Abstract

The use of nanoparticles as carriers of photosensitizer (PS) molecules for photodynamic therapy (PDT) has attracted much interest on core-shell nanosize structures. Herein, we used a simple aqueous solution method to synthesize Fe3O4/ZnO core-shell nanoparticles. X-ray diffraction (XRD) analyses showed the presence of well defined peaks corresponding to Fe3O4 and ZnO in as-synthesized nanocrystals. Vibrating sample magnetometer (VSM) measurements showed that these nanoparticles exhibited superparamagnetic behavior of the core with no coercivity nor remanence. X-ray photoelectron spectroscopy (XPS) analyses revealed the presence of Zn1/2 and Zn3/2 species on the surface of nanocrystals. Photoluminescence measurements showed excitonic emission of ZnO co-existing with a weak and broad defect- related green emission at room temperature. The generation of singlet oxygen was monitored via the photooxidation of diphenyl-1,3-isobenzofuran (DPBF) with different light sources, followed by absorption spectroscopy at 409 nm. The capability of synthesized nanoparticles to generate singlet oxygen has also been verified.

Keywords

core/shellmagneticbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1257: Symposium O – Multifunctional Nanoparticle Systems-Coupled Behavior and Applications , 2010 , 1257-O06-04
Copyright
Copyright © Materials Research Society 2010

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