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Biomedical Engineered Ferrofluids

Published online by Cambridge University Press:  26 February 2011

Birgit Fischer ,
Leidong Mao ,
Mustafa Gungormus ,
Candan Tamerler-Behar ,
Mehmet Sarikaya  and
Hur Koser
Birgit Fischer
Affiliation:
birgit.fischer@yale.edu, Yale University, Electrical Engineering, 15 Prospect St., Becton Center #608, New Haven, CT, 06520, United States, (203) 432 8573, (203) 432 6420
Leidong Mao
Affiliation:
Leidong.mao@yale.edu, Yale University, Electrical Engineering, New Haven, CT, 06520, United States
Mustafa Gungormus
Affiliation:
musgun@u.washington.edu, University of Washington, Materials Science and Engineering, Seattle, WA, 98195, United States
Candan Tamerler-Behar
Affiliation:
candan@u.washington.edu, University of Washington, Materials Science and Engineering, Seattle, WA, 98195, United States
Mehmet Sarikaya
Affiliation:
sarikaya@u.washington.edu, University of Washington, Materials Science and Engineering, Seattle, WA, 98195, United States
Hur Koser
Affiliation:
hur.koser@yale.edu, Yale University, Electrical Engineering, New Haven, CT, 06520, United States
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Abstract

The characteristic of combining liquid behavior with and magnetic properties makes ferrofluids unique and it provides them a variety of applications, in particular in the medial field. For medical application ferrofluids are required to be stable at neutral pH and against high salt concentration. Here we present a new approach to stabilize water-based ferrofluids by using genetically engineered peptides for inorganics (GEPI's). Such GEPI's selected for specific and strong binding to the surface of nanoparticles not only increase colloidal stability by acting as a thin surfactant, but they also enable an efficient route for rendering the ferrofluid bio-functional and bio-compatible. The stability of a ferrofluid was characterized by the ac-susceptibility and by using it in a ferro-microfluidic device. This chip actuates the ferrofluid directly via magnetic fields alone, and the pumping spectrum as a function of frequency reveals information about the size of the magnetic nanoparticles. An ideal ferrofluid with monodisperse particles displays a single and clear pumping peak. Agglomeration can directly be observed as a broadening of the pumping spectrum.

Keywords

biomaterialcolloidmagnetic
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1032: Symposium I – Nanoscale Magnetic Materials and Applications , 2007 , 1032-I15-07
Copyright
Copyright © Materials Research Society 2008

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