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Development of Novel Biodegradable Amino Acid Ester Based Polyphosphazene– Hydroxyapatite Composites for Bone Tissue Engineering

Published online by Cambridge University Press:  01 February 2011

Swaminathan Sethuraman ,
Lakshmi S. Nair ,
Anurima Singh ,
Jared D Bender ,
Yaser E. Greish ,
Paul W. Brown ,
Harry R. Allcock  and
Cato T. Laurencin
Swaminathan Sethuraman
Affiliation:
Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA.
Lakshmi S. Nair
Affiliation:
Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA.
Anurima Singh
Affiliation:
Department of Chemistry, Pennsylvania State University, University Park, PA, USA.
Jared D Bender
Affiliation:
Department of Chemistry, Pennsylvania State University, University Park, PA, USA.
Yaser E. Greish
Affiliation:
Intercollege Materials Research Laboratory, Pennsylvania State University, University Park, PA, USA.
Paul W. Brown
Affiliation:
Intercollege Materials Research Laboratory, Pennsylvania State University, University Park, PA, USA.
Harry R. Allcock
Affiliation:
Department of Chemistry, Pennsylvania State University, University Park, PA, USA.
Cato T. Laurencin*
Affiliation:
Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA. Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
*
* Corresponding Author: Cato T.Laurencin M.D., Ph.D., University Professor Lillian T.Pratt Distinguished Professor and Chairman of Orthopaedic Surgery Professor of Biomedical Engineering Professor of Chemical Engineering 400 Ray C.Hunt Drive, Suite 330, University of Virginia, Charlottesville, VA 22903., Ph: 434 243 0250, Fax: 434 243 0252, Email: laurencin@virginia.edu
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Astract:

Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P – 1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50%ethyl alanato) (50%methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.

Keywords

Low temperature setting calcium phosphate cementsPolyphosphazenesCompositesBone tissue engineering
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA5.22
Copyright
Copyright © Materials Research Society 2005

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References

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