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Fabrication of Piezoelectric Sensors for Biomedical Applications

Published online by Cambridge University Press:  10 February 2011

Iqbal Hussajn ,
Ashok Kumar ,
A. Mangiaracina ,
S. C. Perlaky ,
S. C. Mccombs ,
F. Zhong ,
J. J. Weimer  and
L. Sanderson
Iqbal Hussajn
Affiliation:
Dept. of Electrical Engineering, University of South Alabama, Mobile, AL 36688
Ashok Kumar
Affiliation:
Dept. of Electrical Engineering, University of South Alabama, Mobile, AL 36688
A. Mangiaracina
Affiliation:
Dept. of Electrical Engineering, University of South Alabama, Mobile, AL 36688
S. C. Perlaky
Affiliation:
Dept. of Medicine, University of South Alabama, Mobile, AL 36688
S. C. Mccombs
Affiliation:
Dept. of Medicine, University of South Alabama, Mobile, AL 36688
F. Zhong
Affiliation:
Dept. of Medicine, University of South Alabama, Mobile, AL 36688
J. J. Weimer
Affiliation:
Dept. of Chemistry & Materials Engr., University of Alabama in Huntsville, AL 35899
L. Sanderson
Affiliation:
Dept. of Chemistry & Materials Engr., University of Alabama in Huntsville, AL 35899
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Abstract

Biosensors are a special class of chemical sensors that take advantage of the high selectivity and sensitivity of biologically active material. We are currently investigating the characteristics of various deposited electrode coatings (Au and Pt) on 10 MHz quartz crystals using the sputtering method. We are also investigating the effect of magnetic behavior (by intermixing Fe and Ni with electrodes) on the binding nature of antigen with the substrate. A change in mass occurs due to the binding of antigens and antibodies on the surface of the thin film coating. The frequency change as a result of a change in mass makes it possible to use these crystals as biological sensor devices. This paper describes the construction of antibody-based piezoelectric crystals capable of detecting mycobacterial antigens in diluted cultures of attenuated M. tuberculosis. The microstructural features of these crystals have been studied using scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. The crystallographic properties have been characterized using the X-ray diffraction (XRD) method. The long term objective of this research is to develop a rapid quantitative method of analysis for the diagnosis of tuberculosis (TB) and other infections caused by mycobacteria, using biosensor technology.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 459: Symposium Y – Materials for Smart Systems II , 1996 , 501
Copyright
Copyright © Materials Research Society 1997

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References

REFERENCES

[1] Ward, M. D. and Buttry, D. A., Science, 248, 1000 (1990)Google Scholar
[2] Morgan, H. and Taylor, D. M., Biosensors and Bioefectronics, 7, 405 (1992)Google Scholar
[3] Alberte, R. S., Naval Res. Reviews, 3, 2, (1994)Google Scholar
[4] Dewa, A.S. and Ko, W.H., Semiconductor Sensors, Ed. Sze, S. M., Wiley, J. (New York), 415 (1994)Google Scholar
[5] Guilbault, G. G. and Jordan, J. M., CRC Crit. Rev. Anal. Chem., 19, issue 1, 1 (1988)Google Scholar
[6] Hahn, E. C., Ph.D. Thesis, Dept. of Chemistry, Univ. New Orleans (1988)Google Scholar
[7] Muramatsu, H., Dicks, J. M., Taniya, E. and Karube, I., Anal. Chem., 59, 2760 (1987)Google Scholar
[8] Murray, C. J. L., Styblo, K. and Rouillon, A., Disease Control Priorities in Developing Countries, Oxford Univ. Press for the World Bank (New York), 50 (1992); Bull Int Unton Tuberc, 24 (1990)Google Scholar
[9] Bloom, B. R. and Murray, C. J. L., Science, 257, 1055 (1992)Google Scholar
[10] Arango, L., Brewin, A.W. and Murray, J. F., Amer. Rev. Respir. Dis., 108, 805 (1978)Google Scholar
[11] Weissler, J. C., Amer J. of Med. Sci, 305, 52 (1993)Google Scholar
[12] Hussain, I., Kumar, A. et al. (Unpublished)Google Scholar